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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
View ORCID ProfileC.C. Robertson, View ORCID ProfileJ.R.J. Inshaw, S. Onengut-Gumuscu, W.M. Chen, D. Flores Santa Cruz, H. Yang, A.J. Cutler, D.J.M. Crouch, E. Farber, S.L. Bridges Jr., J.C. Edberg, R.P. Kimberly, J.H. Buckner, P. Deloukas, J. Divers, D. Dabelea, J.M. Lawrence, S. Marcovina, A.S. Shah, C.J. Greenbaum, M.A. Atkinson, P.K. Gregersen, J.R. Oksenberg, F. Pociot, M.J. Rewers, A.K. Steck, D.B. Dunger, Type 1 Diabetes Genetics Consortium, L.S. Wicker, P. Concannon, J.A. Todd, S.S. Rich
doi: https://doi.org/10.1101/2020.06.19.158071
C.C. Robertson
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
J.R.J. Inshaw
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
S. Onengut-Gumuscu
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
W.M. Chen
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
D. Flores Santa Cruz
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
H. Yang
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
A.J. Cutler
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
D.J.M. Crouch
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
E. Farber
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
S.L. Bridges Jr.
4Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
J.C. Edberg
4Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
R.P. Kimberly
4Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
J.H. Buckner
5Center for Translational Immunology, Benaroya Research Institute, Seattle, Washington, USA
P. Deloukas
6Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
7Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
J. Divers
8Division of Health Services Research, Department of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, New York, USA
D. Dabelea
9Colorado School of Public Health and Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus
J.M. Lawrence
10Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA
S. Marcovina
11Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington, USA
A.S. Shah
12Cincinnati Children’s Hospital Medical Center & the University of Cincinnati, Cincinnati, Ohio, USA
C.J. Greenbaum
13Center for Interventional Immunology, Benaroya Research Institute, Seattle, Washington, USA
14Diabetes Program, Benaroya Research Institute, Seattle, Washington, USA
M.A. Atkinson
15Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
P.K. Gregersen
16Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA
J.R. Oksenberg
17Department of Neurology and Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, California, USA
F. Pociot
18Department of Pediatrics, Herlev University Hospital, Copenhagen, Denmark
19Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
20Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark
M.J. Rewers
21Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA
A.K. Steck
21Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA
D.B. Dunger
22Department of Paediatrics, University of Cambridge, Cambridge, UK
23Wellcome Trust Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge UK
L.S. Wicker
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
P. Concannon
15Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
24Genetics Institute, University of Florida, Gainesville, Florida, USA
J.A. Todd
2JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
25JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
S.S. Rich
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
3Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
26Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Posted June 20, 2020.
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
C.C. Robertson, J.R.J. Inshaw, S. Onengut-Gumuscu, W.M. Chen, D. Flores Santa Cruz, H. Yang, A.J. Cutler, D.J.M. Crouch, E. Farber, S.L. Bridges Jr., J.C. Edberg, R.P. Kimberly, J.H. Buckner, P. Deloukas, J. Divers, D. Dabelea, J.M. Lawrence, S. Marcovina, A.S. Shah, C.J. Greenbaum, M.A. Atkinson, P.K. Gregersen, J.R. Oksenberg, F. Pociot, M.J. Rewers, A.K. Steck, D.B. Dunger, Type 1 Diabetes Genetics Consortium, L.S. Wicker, P. Concannon, J.A. Todd, S.S. Rich
bioRxiv 2020.06.19.158071; doi: https://doi.org/10.1101/2020.06.19.158071
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
C.C. Robertson, J.R.J. Inshaw, S. Onengut-Gumuscu, W.M. Chen, D. Flores Santa Cruz, H. Yang, A.J. Cutler, D.J.M. Crouch, E. Farber, S.L. Bridges Jr., J.C. Edberg, R.P. Kimberly, J.H. Buckner, P. Deloukas, J. Divers, D. Dabelea, J.M. Lawrence, S. Marcovina, A.S. Shah, C.J. Greenbaum, M.A. Atkinson, P.K. Gregersen, J.R. Oksenberg, F. Pociot, M.J. Rewers, A.K. Steck, D.B. Dunger, Type 1 Diabetes Genetics Consortium, L.S. Wicker, P. Concannon, J.A. Todd, S.S. Rich
bioRxiv 2020.06.19.158071; doi: https://doi.org/10.1101/2020.06.19.158071
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