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Analysis of receptor-ligand pairings and distribution of myeloid subpopulations across the animal kingdom reveals neutrophil evolution was facilitated by colony-stimulating factors

Damilola Pinheiro, Marie-Anne Mahwin, Maria Prendecki, View ORCID ProfileKevin J Woollard
doi: https://doi.org/10.1101/2020.06.19.161059
Damilola Pinheiro
1Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London. London. W12 0NN
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  • For correspondence: d.pinheiro@imperial.ac.uk k.woollard@imperial.ac.uk
Marie-Anne Mahwin
1Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London. London. W12 0NN
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Maria Prendecki
1Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London. London. W12 0NN
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Kevin J Woollard
1Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London. London. W12 0NN
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  • ORCID record for Kevin J Woollard
  • For correspondence: d.pinheiro@imperial.ac.uk k.woollard@imperial.ac.uk
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Abstract

Neutrophils or heterophils constitute the largest population of phagocytic granulocytes in the blood of mammals and birds. The development and function of neutrophils and monocytes is primarily governed by the granulocyte colony-stimulating factor receptor family (CSF3R/CSF3) and macrophage colony-stimulating factor receptor family (CSF1R/IL34/CSF1) respectively. Using various techniques this study considered how the emergence of receptor:ligand pairings shaped the distribution of blood myeloid cell populations. Comparative gene analysis supported the ancestral pairings of CSF1R/IL34 and CSF3R/CSF3, and the emergence of CSF1 later in tetrapod lineages after the advent of Jawed/Jawless fish. Further analysis suggested that the emergence of CSF3 lead to reorganisation of granulocyte distribution between amphibian and early reptiles. However, the advent of endothermy likely contributed to the dominance of the neutrophil/heterophil in modern-day mammals and birds. In summary, we show that the emergence of CSF3R/CSF3 was a key factor in the subsequent evolution of the modern-day mammalian neutrophil.

Impact statement Colony-stimulating factors (CSFs) are important for myeloid phagocyte development. The emergence of CSF3/CSF3R in tetrapod lineages has uniquely contributed to physical, functional and structural adaptions observed in mammalian neutrophils.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted July 04, 2020.
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Analysis of receptor-ligand pairings and distribution of myeloid subpopulations across the animal kingdom reveals neutrophil evolution was facilitated by colony-stimulating factors
Damilola Pinheiro, Marie-Anne Mahwin, Maria Prendecki, Kevin J Woollard
bioRxiv 2020.06.19.161059; doi: https://doi.org/10.1101/2020.06.19.161059
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Analysis of receptor-ligand pairings and distribution of myeloid subpopulations across the animal kingdom reveals neutrophil evolution was facilitated by colony-stimulating factors
Damilola Pinheiro, Marie-Anne Mahwin, Maria Prendecki, Kevin J Woollard
bioRxiv 2020.06.19.161059; doi: https://doi.org/10.1101/2020.06.19.161059

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