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Measurement of stretch-evoked brainstem function using fMRI

View ORCID ProfileAndrea Zonnino, View ORCID ProfileAndria J Farrens, View ORCID ProfileDavid Ress, View ORCID ProfileFabrizio Sergi
doi: https://doi.org/10.1101/2020.06.19.161315
Andrea Zonnino
1Human Robotics Laboratory, Department of Biomedical Engineering, University of Delaware, Newark DE, 19713, USA
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Andria J Farrens
1Human Robotics Laboratory, Department of Biomedical Engineering, University of Delaware, Newark DE, 19713, USA
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David Ress
2Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77020, USA
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Fabrizio Sergi
1Human Robotics Laboratory, Department of Biomedical Engineering, University of Delaware, Newark DE, 19713, USA
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  • For correspondence: fabs@udel.edu
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ABSTRACT

Knowledge on the organization of motor function in the reticulospinal tract (RST) is limited by the lack of methods for measuring RST function in humans. Behavioral studies suggest the involvement of the RST in long latency responses (LLRs). LLRs, elicited by precisely controlled perturbations, can therefore act as a viable paradigm to measure motor-related RST activity using functional Magnetic Resonance Imaging (fMRI).

Here we present StretchfMRI, a novel technique developed to study RST function associated with LLRs. StretchfMRI combines robotic perturbations with electromyography and fMRI to simultaneously quantify muscular and neural activity during stretch-evoked LLRs without loss of reliability. Using StretchfMRI, we established the muscle-specific organization of LLR activity in the brainstem. The observed organization is partially consistent with animal models, with activity primarily in the ipsilateral medulla for flexors and in the contralateral pons for extensors, but also include other areas, such as the midbrain and bilateral pontomedullary contributions.

Competing Interest Statement

AZ and FS are co-inventors of a provisional patent application on the method for EMG acquisition during fMRI.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 20, 2020.
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Measurement of stretch-evoked brainstem function using fMRI
Andrea Zonnino, Andria J Farrens, David Ress, Fabrizio Sergi
bioRxiv 2020.06.19.161315; doi: https://doi.org/10.1101/2020.06.19.161315
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Measurement of stretch-evoked brainstem function using fMRI
Andrea Zonnino, Andria J Farrens, David Ress, Fabrizio Sergi
bioRxiv 2020.06.19.161315; doi: https://doi.org/10.1101/2020.06.19.161315

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