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Analysis of SARS-CoV-2 specific T-cell receptors in ImmuneCode reveals cross-reactivity to immunodominant Influenza M1 epitope

View ORCID ProfileJohn-William Sidhom, View ORCID ProfileAlexander S. Baras
doi: https://doi.org/10.1101/2020.06.20.160499
John-William Sidhom
Johns Hopkins University School of Medicine
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  • For correspondence: jsidhom1@jhmi.edu
Alexander S. Baras
Johns Hopkins University School of Medicine
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Abstract

Adaptive Biotechnologies and Microsoft have recently partnered to release ImmuneCode, a database containing SARS-CoV-2 specific T-cell receptors derived through MIRA, a T-cell receptor (TCR) sequencing based sequencing approach to identify antigen-specific TCRs. Herein, we query the extent of cross reactivity between these derived SARS-CoV-2 specific TCRs and other known antigens present in McPas-TCR, a manually curated catalogue of pathology-associated TCRs. We reveal cross reactivity between SARS-CoV-2 specific TCRs and the immunodominant Influenza GILGFVFTL M1 epitope, suggesting the importance of further work in characterizing the implications of prior Influenza exposure or co-exposure to the pathology of SARS-CoV-2 illness.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://github.com/sidhomj/COVID19

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 20, 2020.
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Analysis of SARS-CoV-2 specific T-cell receptors in ImmuneCode reveals cross-reactivity to immunodominant Influenza M1 epitope
John-William Sidhom, Alexander S. Baras
bioRxiv 2020.06.20.160499; doi: https://doi.org/10.1101/2020.06.20.160499
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Analysis of SARS-CoV-2 specific T-cell receptors in ImmuneCode reveals cross-reactivity to immunodominant Influenza M1 epitope
John-William Sidhom, Alexander S. Baras
bioRxiv 2020.06.20.160499; doi: https://doi.org/10.1101/2020.06.20.160499

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