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fruitless tunes functional flexibility of courtship circuitry during development

Jie Chen, Sihui Jin, Jie Cao, Qionglin Peng, View ORCID ProfileYufeng Pan
doi: https://doi.org/10.1101/2020.06.20.163055
Jie Chen
1The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China
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Sihui Jin
1The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China
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Jie Cao
1The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China
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Qionglin Peng
1The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China
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Yufeng Pan
1The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China
2Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226019, China
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  • ORCID record for Yufeng Pan
  • For correspondence: pany@seu.edu.cn
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ABSTRACT

Drosophila male courtship is controlled by the male-specific products of the fruitless (fruM gene and its expressing neuronal circuitry. fruM is considered a master gene that controls all aspects of male courtship. By temporally and spatially manipulating fruM expression, we found that fruM is required during a critical developmental period for innate courtship towards females, and its function during adulthood is relatively trivial. By altering or eliminating fruM expression, we generated males that are innately heterosexual, homosexual, bisexual, or without innate courtship but could acquire such behavior in an experience-dependent manner. These findings show that fruM is not absolutely necessary for courtship but is critical during development to build a sex circuitry with reduced flexibility and enhanced efficiency and provide a new view about how fruM tunes functional flexibility of a sex circuitry.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 20, 2020.
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fruitless tunes functional flexibility of courtship circuitry during development
Jie Chen, Sihui Jin, Jie Cao, Qionglin Peng, Yufeng Pan
bioRxiv 2020.06.20.163055; doi: https://doi.org/10.1101/2020.06.20.163055
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fruitless tunes functional flexibility of courtship circuitry during development
Jie Chen, Sihui Jin, Jie Cao, Qionglin Peng, Yufeng Pan
bioRxiv 2020.06.20.163055; doi: https://doi.org/10.1101/2020.06.20.163055

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