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History
- June 25, 2020.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- E Audain1,2,§,
- A Wilsdon3,§,
- J Breckpot4,
- JMG Izarzugaza5,
- TW Fitzgerald6,
- AK Kahlert1,2,7,
- A Sifrim8,9,
- F Wünnemann10,
- Y Perez-Riverol11,
- H Abdul-Khaliq12,
- M Bak13,14,
- AS Bassett15,16,
- JW Belmont17,18,
- DW Benson19,
- F Berger20,
- I Daehnert21,
- K Devriendt4,
- S Dittrich22,
- P Daubeney23,
- V Garg24,25,26,27,
- K Hackmann7,
- K Hoff1,2,
- P Hofmann1,2,
- G Dombrowsky1,2,
- T Pickardt28,
- U Bauer28,
- BD Keavney29,30,
- S Klaassen31,32,33,
- HH Kramer1,2,
- CR Marshall34,35,
- DM Milewicz36,
- SA Lemaire37,
- J Coselli38,
- ME Mitchell38,
- A Tomita-Mitchell38,
- SK Prakash36,
- K Stamm38,
- AFR Stewart39,
- CK Silversides15,
- R Siebert40,41,
- B Stiller42,
- JA Rosenfeld17,
- I Vater41,
- AV Postma43,44,
- A Caliebe41,
- JD Brook3,
- G Andelfinger45,
- ME Hurles46,
- B Thienpont4,47,
- LA Larsen13,* and
- MP Hitz1,2,41,46,*
- 1Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany
- 2German Center for Cardiovascular Research (DZHK), Kiel, Germany
- 3School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
- 4Centre for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
- 5Department of Health Technology, Technical University of Denmark, Kemitorvet, DK-2800 Kgs. Lyngby, Denmark
- 6European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, CB10 1SD, UK
- 7Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
- 8Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium
- 9Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK
- 10Montreal Heart Institute, Université de Montréal, Québec, Canada
- 11European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
- 12Clinic for Pediatric Cardiology - University Hospital of Saarland, Kirrberger Strasse, 66421 Homburg (Saar), Germany
- 13Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
- 14Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
- 15Toronto Congenital Cardiac Centre for Adults, and Division of Cardiology, Department of Medicine, University Health Network, Toronto, ON, Canada
- 16Toronto General Hospital Research Institute, University Health Network; Clinical Genetics Research Program and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- 17Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA
- 18USDA/ARS/Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
- 19Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA
- 20Department of Congenital Heart Disease - Pediatric Cardiology, German Heart Center Berlin, Berlin, Germany
- 21Department of Pediatric Cardiology and Congenital Heart Disease, Heart Center, University of Leipzig, Leipzig, Germany
- 22Department of Pediatric Cardiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
- 23Division of Paediatric Cardiology, Royal Brompton Hospital, London, UK; Paediatric Cardiology, Imperial College, London, UK
- 24The Heart Center, Nationwide Children’s Hospital, Columbus, OH 43205, USA
- 25Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
- 26Center for Cardiovascular Research, Nationwide Children’s Hospital, Columbus, OH 43205, USA
- 27Department of Pediatrics, The Ohio State University, Columbus, OH 43210, USA
- 28DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany; Competence Network for Congenital Heart Defects, Berlin, Germany
- 29Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
- 30Division of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
- 31Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany
- 32Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Cardiology, Berlin, Germany
- 33DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
- 34The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
- 35Genome Diagnostics, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada
- 36Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 37Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
- 38Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, 53226, USA
- 39Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
- 40Institute of Human Genetics, University Hospital Ulm, Ulm, Germany
- 41Department of Human Genetics, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany
- 42Department of Congenital Heart Disease and Pediatric Cardiology, University Heart Center Freiburg - Bad Krozingen, Freiburg, Germany
- 43Department of Medical Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
- 44Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
- 45Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Saint-Justine Research Centre, Université de Montréal, Montreal, QC, Canada
- 46Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
- 47Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium
- ↵*Corresponding authors: Lars Allan Larsen, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark, Tel: +45 3532 7827, Fax: +45 3532 6042, Email: larsal{at}sund.ku.dk, Marc-Phillip Hitz, Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Arnold-Heller-Straße 3, Haus 9, 24105 Kiel, Germany. Tel: +49 (0)431 500 – 30626; Fax. +49 (0)431 500 – 25604, Email: Marc-Phillip.Hitz{at}uksh.de
↵§ These authors contributed equally to the work.