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In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
View ORCID ProfileBeata Turoňová, View ORCID ProfileMateusz Sikora, View ORCID ProfileChristoph Schürmann, View ORCID ProfileWim J. H. Hagen, View ORCID ProfileSonja Welsch, View ORCID ProfileFlorian E. C. Blanc, View ORCID ProfileSören von Bülow, View ORCID ProfileMichael Gecht, Katrin Bagola, View ORCID ProfileCindy Hörner, Ger van Zandbergen, View ORCID ProfileShyamal Mosalaganti, View ORCID ProfileAndre Schwarz, View ORCID ProfileRoberto Covino, View ORCID ProfileMichael D. Mühlebach, View ORCID ProfileGerhard Hummer, View ORCID ProfileJacomine Krijnse Locker, View ORCID ProfileMartin Beck
doi: https://doi.org/10.1101/2020.06.26.173476
Beata Turoňová
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr. 1, Germany
2Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Mateusz Sikora
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Christoph Schürmann
4Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
Wim J. H. Hagen
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr. 1, Germany
Sonja Welsch
5Central electron microscopy facility, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Florian E. C. Blanc
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Sören von Bülow
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Michael Gecht
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Katrin Bagola
7Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
Cindy Hörner
4Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
8German Center for Infection Research, Gießen-Marburg-Langen, Germany
Ger van Zandbergen
7Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
9Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
10Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany
Shyamal Mosalaganti
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr. 1, Germany
2Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Andre Schwarz
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr. 1, Germany
Roberto Covino
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
11Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany
Michael D. Mühlebach
4Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
8German Center for Infection Research, Gießen-Marburg-Langen, Germany
Gerhard Hummer
3Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
6Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany
Jacomine Krijnse Locker
12Electron Microscopy of Pathogens Unit, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany
Martin Beck
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr. 1, Germany
2Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany
Posted June 26, 2020.
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
Beata Turoňová, Mateusz Sikora, Christoph Schürmann, Wim J. H. Hagen, Sonja Welsch, Florian E. C. Blanc, Sören von Bülow, Michael Gecht, Katrin Bagola, Cindy Hörner, Ger van Zandbergen, Shyamal Mosalaganti, Andre Schwarz, Roberto Covino, Michael D. Mühlebach, Gerhard Hummer, Jacomine Krijnse Locker, Martin Beck
bioRxiv 2020.06.26.173476; doi: https://doi.org/10.1101/2020.06.26.173476
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
Beata Turoňová, Mateusz Sikora, Christoph Schürmann, Wim J. H. Hagen, Sonja Welsch, Florian E. C. Blanc, Sören von Bülow, Michael Gecht, Katrin Bagola, Cindy Hörner, Ger van Zandbergen, Shyamal Mosalaganti, Andre Schwarz, Roberto Covino, Michael D. Mühlebach, Gerhard Hummer, Jacomine Krijnse Locker, Martin Beck
bioRxiv 2020.06.26.173476; doi: https://doi.org/10.1101/2020.06.26.173476
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