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RNA Atlas of Human Bacterial Pathogens Uncovers Stress Dynamics Linked to Infection

View ORCID ProfileKemal Avican, Jehad Aldahdooh, Matteo Togninalli, Jing Tang, Karsten M. Borgwardt, Mikael Rhen, View ORCID ProfileMaria Fällman
doi: https://doi.org/10.1101/2020.06.29.177147
Kemal Avican
1Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial research (UCMR), Umeå University, Umeå, 90187, Sweden
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  • ORCID record for Kemal Avican
  • For correspondence: kemal.avican@umu.se maria.fallman@umu.se
Jehad Aldahdooh
2Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland
3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland
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Matteo Togninalli
4Department for Biosystems Science and Engineering, ETH Zürich, Basel, 4058, Switzerland
5Swiss Institute for Bioinformatics, Switzerland
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Jing Tang
2Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland
3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland
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Karsten M. Borgwardt
4Department for Biosystems Science and Engineering, ETH Zürich, Basel, 4058, Switzerland
5Swiss Institute for Bioinformatics, Switzerland
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Mikael Rhen
6Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, 17165, Sweden
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Maria Fällman
1Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial research (UCMR), Umeå University, Umeå, 90187, Sweden
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  • ORCID record for Maria Fällman
  • For correspondence: kemal.avican@umu.se maria.fallman@umu.se
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Abstract

Despite being genetically diverse, bacterial pathogens can adapt to similar stressful environments in human host, but how this diversity allows them to achive this is yet not fully understood. Knowledge gained through comparative genomics is insufficient as it lacks the level of gene expression reflecting gene usage. To fill this gap, we investigated the transcriptome of 32 diverse bacterial pathogens under 11 host related stress conditions. We revealed that diverse bacterial pathogens have common responses to similar stresses to a certain extent but mostly employ their unique repertoire with intersections between different stress responses. We also identified universal stress responders which shed light on the nature of antimicrobial targets. In addition, we found that known and unknown putative novel ncRNAs comprised a significant proportion of the responses. All the data is collected in PATHOgenex atlas, providing ample opportunities to discover novel players critical for virulence and maintenance of infection.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵7 Lead contact

  • http://pathogenex.org/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 29, 2020.
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RNA Atlas of Human Bacterial Pathogens Uncovers Stress Dynamics Linked to Infection
Kemal Avican, Jehad Aldahdooh, Matteo Togninalli, Jing Tang, Karsten M. Borgwardt, Mikael Rhen, Maria Fällman
bioRxiv 2020.06.29.177147; doi: https://doi.org/10.1101/2020.06.29.177147
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RNA Atlas of Human Bacterial Pathogens Uncovers Stress Dynamics Linked to Infection
Kemal Avican, Jehad Aldahdooh, Matteo Togninalli, Jing Tang, Karsten M. Borgwardt, Mikael Rhen, Maria Fällman
bioRxiv 2020.06.29.177147; doi: https://doi.org/10.1101/2020.06.29.177147

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