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Hemispheric specialization within the inferior parietal lobe across cognitive domains

Ole Numssen, Danilo Bzdok, Gesa Hartwigsen
doi: https://doi.org/10.1101/2020.07.01.181602
Ole Numssen
1Lise Meitner Research Group “Cognition and Plasticity”, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany
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Danilo Bzdok
2Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, McGill University, Montreal, Canada
3Mila - Quebec Artificial Intelligence Institute, Montreal, Canada
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  • For correspondence: danilo.bzdok@mcgill.ca hartwigsen@cbs.mpg.de
Gesa Hartwigsen
1Lise Meitner Research Group “Cognition and Plasticity”, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany
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  • For correspondence: danilo.bzdok@mcgill.ca hartwigsen@cbs.mpg.de
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Abstract

The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental processes, from basic attention to language and social cognition that define human interactions. Its putative domain-global role appears to tie into poorly understood functional differences between both hemispheres. Across attentional, semantic, and social cognitive experiments, our study explored hemispheric specialization within the IPL. The task specificity of IPL subregion activity was substantiated by distinct predictive signatures identified by multivariate pattern-learning algorithms. Moreover, the left and right IPL exerted domain-specific modulation of effective connectivity among their subregions. Task-evoked functional interactions of the anterior and posterior IPL subregions involved recruitment of distributed cortical partners. While each anterior IPL subregion was engaged in strongly lateralized coupling links, both posterior subregions showed more symmetric coupling patterns across hemispheres. Our collective results shed light on how under-appreciated lateralization effects within the IPL support some of the most distinctive human mental capacities.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵# shared senior authorship

  • http://gitlab.gwdg.de/IPLplasticity/FuncSeg

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted September 29, 2020.
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Hemispheric specialization within the inferior parietal lobe across cognitive domains
Ole Numssen, Danilo Bzdok, Gesa Hartwigsen
bioRxiv 2020.07.01.181602; doi: https://doi.org/10.1101/2020.07.01.181602
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Hemispheric specialization within the inferior parietal lobe across cognitive domains
Ole Numssen, Danilo Bzdok, Gesa Hartwigsen
bioRxiv 2020.07.01.181602; doi: https://doi.org/10.1101/2020.07.01.181602

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