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A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike
Tongqing Zhou, Yaroslav Tsybovsky, Adam S. Olia, Jason Gorman, Micah A. Rapp, Gabriele Cerutti, Phinikoula S. Katsamba, Alexandra Nazzari, Arne Schön, Pengfei Wang, Jude Bimela, Wei Shi, I-Ting Teng, Baoshan Zhang, Jeffrey C. Boyington, Gwo-Yu Chuang, Jared M. Sampson, Mallika Sastry, Tyler Stephens, Jonathan Stuckey, Shuishu Wang, Richard A. Friesner, David D. Ho, John R. Mascola, Lawrence Shapiro, Peter D. Kwong
doi: https://doi.org/10.1101/2020.07.04.187989
Tongqing Zhou
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Yaroslav Tsybovsky
2Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Adam S. Olia
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Jason Gorman
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Micah A. Rapp
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Gabriele Cerutti
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Phinikoula S. Katsamba
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Alexandra Nazzari
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Arne Schön
4Department of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA
Pengfei Wang
5Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA
Jude Bimela
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Wei Shi
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
I-Ting Teng
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Baoshan Zhang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Jeffrey C. Boyington
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Gwo-Yu Chuang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Jared M. Sampson
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
6Department of Chemistry, Columbia University, New York, NY 10027, USA
Mallika Sastry
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Tyler Stephens
2Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Jonathan Stuckey
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Shuishu Wang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Richard A. Friesner
6Department of Chemistry, Columbia University, New York, NY 10027, USA
David D. Ho
5Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA
John R. Mascola
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Lawrence Shapiro
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
5Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA
Peter D. Kwong
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
3Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Posted July 04, 2020.
A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike
Tongqing Zhou, Yaroslav Tsybovsky, Adam S. Olia, Jason Gorman, Micah A. Rapp, Gabriele Cerutti, Phinikoula S. Katsamba, Alexandra Nazzari, Arne Schön, Pengfei Wang, Jude Bimela, Wei Shi, I-Ting Teng, Baoshan Zhang, Jeffrey C. Boyington, Gwo-Yu Chuang, Jared M. Sampson, Mallika Sastry, Tyler Stephens, Jonathan Stuckey, Shuishu Wang, Richard A. Friesner, David D. Ho, John R. Mascola, Lawrence Shapiro, Peter D. Kwong
bioRxiv 2020.07.04.187989; doi: https://doi.org/10.1101/2020.07.04.187989
A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike
Tongqing Zhou, Yaroslav Tsybovsky, Adam S. Olia, Jason Gorman, Micah A. Rapp, Gabriele Cerutti, Phinikoula S. Katsamba, Alexandra Nazzari, Arne Schön, Pengfei Wang, Jude Bimela, Wei Shi, I-Ting Teng, Baoshan Zhang, Jeffrey C. Boyington, Gwo-Yu Chuang, Jared M. Sampson, Mallika Sastry, Tyler Stephens, Jonathan Stuckey, Shuishu Wang, Richard A. Friesner, David D. Ho, John R. Mascola, Lawrence Shapiro, Peter D. Kwong
bioRxiv 2020.07.04.187989; doi: https://doi.org/10.1101/2020.07.04.187989
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