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The severity of microstrokes depends on local vascular topology and baseline perfusion

View ORCID ProfileFranca Schmid, Giulia Conti, View ORCID ProfilePatrick Jenny, View ORCID ProfileBruno Weber
doi: https://doi.org/10.1101/2020.07.05.188565
Franca Schmid
1Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
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  • ORCID record for Franca Schmid
  • For correspondence: franca.schmid@uzh.ch bweber@pharma.uzh.ch
Giulia Conti
2Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland
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Patrick Jenny
2Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland
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Bruno Weber
1Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
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  • For correspondence: franca.schmid@uzh.ch bweber@pharma.uzh.ch
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1 Abstract

Cortical microinfarcts are caused by blood flow disturbances and are linked to pathologies like cerebral amyloid angiopathy and dementia. Despite their relevance for disease progression, microinfarcts often remain undetected and the smallest scale of disturbance has not yet been identified. We employ blood flow simulations in realistic microvascular networks from the mouse cortex to quantify the impact of single capillary occlusions. We reveal that the severity of a microstroke is strongly affected by the local vascular topology and the baseline flow rate in the occluded capillary. The largest changes in flow rate are observed in capillaries with two in- and two outflows. Interestingly, this specific topological configuration only occurs with a frequency of 8%, while the majority of capillaries are likely designed to efficiently supply oxygen and nutrients. Taken together, microstrokes likely induce a cascade of local disturbances in the surrounding tissue, which might accumulate and impair energy supply locally.

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  • Joint last author: Patrick Jenny and Bruno Weber

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 06, 2020.
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The severity of microstrokes depends on local vascular topology and baseline perfusion
Franca Schmid, Giulia Conti, Patrick Jenny, Bruno Weber
bioRxiv 2020.07.05.188565; doi: https://doi.org/10.1101/2020.07.05.188565
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The severity of microstrokes depends on local vascular topology and baseline perfusion
Franca Schmid, Giulia Conti, Patrick Jenny, Bruno Weber
bioRxiv 2020.07.05.188565; doi: https://doi.org/10.1101/2020.07.05.188565

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