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Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection

View ORCID ProfileWenhui Liu, Ruobing Qian, Shiqi Xu, Pavan Chandra Konda, Mark Harfouche, Dawid Borycki, Joakim Jönsson, Edouard Berrocal, Colin Cooke, Allie Sinclair, Haoqian Wang, Qionghai Dai, Roarke W. Horstmeyer
doi: https://doi.org/10.1101/2020.07.08.193433
Wenhui Liu
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
2Department of Automation, Tsinghua University, Beijing, China, 100084
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  • ORCID record for Wenhui Liu
Ruobing Qian
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
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Shiqi Xu
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
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Pavan Chandra Konda
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
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Mark Harfouche
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
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Dawid Borycki
3Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland
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Joakim Jönsson
4Department of Combustion Physics, Lund Institute of Technology, Box 118, Lund 221 00, Sweden
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Edouard Berrocal
4Department of Combustion Physics, Lund Institute of Technology, Box 118, Lund 221 00, Sweden
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Colin Cooke
5Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA, 27708
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Allie Sinclair
6Center for Cognitive Neuroscience, Duke University, Durham, NC, USA, 27708
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Haoqian Wang
7Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China, 518055
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Qionghai Dai
2Department of Automation, Tsinghua University, Beijing, China, 100084
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Roarke W. Horstmeyer
1Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
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  • For correspondence: roarke.w.horstmeyer@duke.edu
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Abstract

Diffuse correlation spectroscopy (DCS) is a well-established method that measures rapid changes in scattered coherent light to identify blood flow and functional dynamics within tissue. While its sensitivity to minute scatterer displacements leads to a number of unique advantages, conventional DCS systems become photon-limited when attempting to probe deep into tissue, which leads to long measurement windows (∼1 sec). Here, we present a high-sensitivity DCS system with 1024 parallel detection channels integrated within a single-photon avalanche diode (SPAD) array, and demonstrate the ability to detect mm-scale perturbations up to 1 cm deep within a tissue-like phantom at up to 33 Hz sampling rate. We also show that this highly parallelized strategy can measure the human pulse at high fidelity and detect behaviorally-induced physiological variations from above the human prefrontal cortex. By greatly improving detection sensitivity and speed, highly parallelized DCS opens up new experiments for high-speed biological signal measurement.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 10, 2020.
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Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection
Wenhui Liu, Ruobing Qian, Shiqi Xu, Pavan Chandra Konda, Mark Harfouche, Dawid Borycki, Joakim Jönsson, Edouard Berrocal, Colin Cooke, Allie Sinclair, Haoqian Wang, Qionghai Dai, Roarke W. Horstmeyer
bioRxiv 2020.07.08.193433; doi: https://doi.org/10.1101/2020.07.08.193433
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Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection
Wenhui Liu, Ruobing Qian, Shiqi Xu, Pavan Chandra Konda, Mark Harfouche, Dawid Borycki, Joakim Jönsson, Edouard Berrocal, Colin Cooke, Allie Sinclair, Haoqian Wang, Qionghai Dai, Roarke W. Horstmeyer
bioRxiv 2020.07.08.193433; doi: https://doi.org/10.1101/2020.07.08.193433

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