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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8+ T cells

View ORCID ProfileAnthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo, Serena J Chee, Benjamin J Meckiff, Hayley Simon, Emanuela Pelosi, Grégory Seumois, Ferhat Ay, Pandurangan Vijayanand, Christian H Ottensmeier
doi: https://doi.org/10.1101/2020.07.09.194027
Anthony Kusnadi
1La Jolla Institute for Immunology, La Jolla, CA, USA
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  • ORCID record for Anthony Kusnadi
Ciro Ramírez-Suástegui
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Vicente Fajardo
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Serena J Chee
2NIHR and CRUK Southampton Experimental Cancer Medicine Center, Faculty of Medicine, University of Southampton, Southampton, UK
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Benjamin J Meckiff
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Hayley Simon
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Emanuela Pelosi
3Southampton Specialist Virology Centre, Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK
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Grégory Seumois
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Ferhat Ay
1La Jolla Institute for Immunology, La Jolla, CA, USA
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Pandurangan Vijayanand
1La Jolla Institute for Immunology, La Jolla, CA, USA
4Liverpool Head and Neck Center, Institute of Translational Medicine, University of Liverpool & Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, United Kingdom
5Department of Medicine, University of California San Diego, La Jolla, CA, USA
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  • For correspondence: vijay@lji.org cottensmeier@lji.org
Christian H Ottensmeier
1La Jolla Institute for Immunology, La Jolla, CA, USA
4Liverpool Head and Neck Center, Institute of Translational Medicine, University of Liverpool & Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, United Kingdom
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  • For correspondence: vijay@lji.org cottensmeier@lji.org
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Article Information

doi 
https://doi.org/10.1101/2020.07.09.194027
History 
  • July 10, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Anthony Kusnadi1,6,
  2. Ciro Ramírez-Suástegui1,6,
  3. Vicente Fajardo1,6,
  4. Serena J Chee2,6,
  5. Benjamin J Meckiff1,
  6. Hayley Simon1,
  7. Emanuela Pelosi3,
  8. Grégory Seumois1,
  9. Ferhat Ay1,
  10. Pandurangan Vijayanand1,4,5,7,* and
  11. Christian H Ottensmeier1,4,7,*
  1. 1La Jolla Institute for Immunology, La Jolla, CA, USA
  2. 2NIHR and CRUK Southampton Experimental Cancer Medicine Center, Faculty of Medicine, University of Southampton, Southampton, UK
  3. 3Southampton Specialist Virology Centre, Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK
  4. 4Liverpool Head and Neck Center, Institute of Translational Medicine, University of Liverpool & Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, United Kingdom
  5. 5Department of Medicine, University of California San Diego, La Jolla, CA, USA
  1. ↵*Correspondence: P.V. (vijay{at}lji.org) or C.H.O (cottensmeier{at}lji.org)
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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8+ T cells
Anthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo, Serena J Chee, Benjamin J Meckiff, Hayley Simon, Emanuela Pelosi, Grégory Seumois, Ferhat Ay, Pandurangan Vijayanand, Christian H Ottensmeier
bioRxiv 2020.07.09.194027; doi: https://doi.org/10.1101/2020.07.09.194027
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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8+ T cells
Anthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo, Serena J Chee, Benjamin J Meckiff, Hayley Simon, Emanuela Pelosi, Grégory Seumois, Ferhat Ay, Pandurangan Vijayanand, Christian H Ottensmeier
bioRxiv 2020.07.09.194027; doi: https://doi.org/10.1101/2020.07.09.194027

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