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SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
Emma S. Winkler, Adam L. Bailey, Natasha M. Kafai, Sharmila Nair, Broc T. McCune, Jinsheng Yu, Julie M. Fox, Rita E. Chen, James T. Earnest, Shamus P. Keeler, Jon H. Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, Michael J. Holtzman, Michael S. Diamond
doi: https://doi.org/10.1101/2020.07.09.196188
Emma S. Winkler
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Adam L. Bailey
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Natasha M. Kafai
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Sharmila Nair
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Broc T. McCune
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Jinsheng Yu
6Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
Julie M. Fox
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Rita E. Chen
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
James T. Earnest
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Shamus P. Keeler
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
4Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Jon H. Ritter
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Liang-I Kang
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Sarah Dort
5SCIREQ Scientific Respiratory Equipment Inc, Montreal (QC), Canada
Annette Robichaud
5SCIREQ Scientific Respiratory Equipment Inc, Montreal (QC), Canada
Richard Head
6Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
Michael J. Holtzman
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
4Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Michael S. Diamond
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
3Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
7The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
Posted July 10, 2020.
SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
Emma S. Winkler, Adam L. Bailey, Natasha M. Kafai, Sharmila Nair, Broc T. McCune, Jinsheng Yu, Julie M. Fox, Rita E. Chen, James T. Earnest, Shamus P. Keeler, Jon H. Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, Michael J. Holtzman, Michael S. Diamond
bioRxiv 2020.07.09.196188; doi: https://doi.org/10.1101/2020.07.09.196188
SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
Emma S. Winkler, Adam L. Bailey, Natasha M. Kafai, Sharmila Nair, Broc T. McCune, Jinsheng Yu, Julie M. Fox, Rita E. Chen, James T. Earnest, Shamus P. Keeler, Jon H. Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, Michael J. Holtzman, Michael S. Diamond
bioRxiv 2020.07.09.196188; doi: https://doi.org/10.1101/2020.07.09.196188
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