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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19

Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
doi: https://doi.org/10.1101/2020.07.09.196337
Douglas Ferreira Sales-Medina
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Ludmila Rodrigues Pinto Ferreira
2RNA Systems Biology Laboratory (RSBL), Post-Graduate Program in Cell Biology, Institute of Biological Sciences, Federal University of Minas Gerais & INCT-Vacinas, Av. Antônio Carlos, 6627, Belo Horizonte-MG 31270910, Brazil
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Lavínia M. D. Romera
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Karolina Ribeiro Gonçalves
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Rafael V. C. Guido
3São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos, SP 13563-120, Brasil São Carlos, Brazil
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Gilles Courtemanche
4Bioaster, 28, rue du Docteur Roux, 75015 Paris, France
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Marcos S. Buckeridge
5Department of Botany, Institute of Biological Sciences, University of Sao Paulo, Rua do Matão, 277, Sao Paulo-SP 05508-900, Brazil
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Édison L. Durigon
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Carolina B. Moraes
6Department of Pharmaceutical Sciences, Federal University of Sao Paulo, Rua São Nicolau, 210, Diadema – SP 09913-030, Brazil
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Lucio H. Freitas-Junior
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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  • For correspondence: luciofreitasjunior@gmail.com
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Article Information

doi 
https://doi.org/10.1101/2020.07.09.196337
History 
  • July 13, 2020.

Article Versions

  • Version 1 (July 10, 2020 - 16:09).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Douglas Ferreira Sales-Medina1,
  2. Ludmila Rodrigues Pinto Ferreira2,
  3. Lavínia M. D. Romera1,
  4. Karolina Ribeiro Gonçalves1,
  5. Rafael V. C. Guido3,
  6. Gilles Courtemanche4,
  7. Marcos S. Buckeridge5,
  8. Édison L. Durigon1,
  9. Carolina B. Moraes6 and
  10. Lucio H. Freitas-Junior1,*
  1. 1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
  2. 2RNA Systems Biology Laboratory (RSBL), Post-Graduate Program in Cell Biology, Institute of Biological Sciences, Federal University of Minas Gerais & INCT-Vacinas, Av. Antônio Carlos, 6627, Belo Horizonte-MG 31270910, Brazil
  3. 3São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos, SP 13563-120, Brasil São Carlos, Brazil
  4. 4Bioaster, 28, rue du Docteur Roux, 75015 Paris, France
  5. 5Department of Botany, Institute of Biological Sciences, University of Sao Paulo, Rua do Matão, 277, Sao Paulo-SP 05508-900, Brazil
  6. 6Department of Pharmaceutical Sciences, Federal University of Sao Paulo, Rua São Nicolau, 210, Diadema – SP 09913-030, Brazil
  1. ↵*Corresponding author: luciofreitasjunior{at}gmail.com
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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
bioRxiv 2020.07.09.196337; doi: https://doi.org/10.1101/2020.07.09.196337
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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
bioRxiv 2020.07.09.196337; doi: https://doi.org/10.1101/2020.07.09.196337

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