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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19

Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
doi: https://doi.org/10.1101/2020.07.09.196337
Douglas Ferreira Sales-Medina
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Ludmila Rodrigues Pinto Ferreira
2RNA Systems Biology Laboratory (RSBL), Post-Graduate Program in Cell Biology, Institute of Biological Sciences, Federal University of Minas Gerais & INCT-Vacinas, Av. Antônio Carlos, 6627, Belo Horizonte-MG 31270910, Brazil
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Lavínia M. D. Romera
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Karolina Ribeiro Gonçalves
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Rafael V. C. Guido
3São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos, SP 13563-120, Brasil São Carlos, Brazil
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Gilles Courtemanche
4Bioaster, 28, rue du Docteur Roux, 75015 Paris, France
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Marcos S. Buckeridge
5Department of Botany, Institute of Biological Sciences, University of Sao Paulo, Rua do Matão, 277, Sao Paulo-SP 05508-900, Brazil
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Édison L. Durigon
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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Carolina B. Moraes
6Department of Pharmaceutical Sciences, Federal University of Sao Paulo, Rua São Nicolau, 210, Diadema – SP 09913-030, Brazil
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Lucio H. Freitas-Junior
1Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Sao Paulo-SP 05508-900, Brazil
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  • For correspondence: luciofreitasjunior@gmail.com
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Posted July 13, 2020.
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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
bioRxiv 2020.07.09.196337; doi: https://doi.org/10.1101/2020.07.09.196337
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Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
Douglas Ferreira Sales-Medina, Ludmila Rodrigues Pinto Ferreira, Lavínia M. D. Romera, Karolina Ribeiro Gonçalves, Rafael V. C. Guido, Gilles Courtemanche, Marcos S. Buckeridge, Édison L. Durigon, Carolina B. Moraes, Lucio H. Freitas-Junior
bioRxiv 2020.07.09.196337; doi: https://doi.org/10.1101/2020.07.09.196337

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