Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Sven H. Schmidt; Jui-Hung Weng; Phillip C. Aoto; Daniela Boassa; Sebastian Mathea; Steven Silletti; Junru Hu; Maximilian Wallbott; Elizabeth A Komives; Stefan Knapp; Friedrich W. Herberg; Susan S. Taylor

doi:10.1101/2020.07.13.198069

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Sven H. Schmidt, View ORCID ProfileJui-Hung Weng, View ORCID ProfilePhillip C. Aoto, Daniela Boassa, View ORCID ProfileSebastian Mathea, Steven Silletti, Junru Hu, Maximilian Wallbott, View ORCID ProfileElizabeth A Komives, View ORCID ProfileStefan Knapp, View ORCID ProfileFriedrich W. Herberg, View ORCID ProfileSusan S. Taylor

doi: https://doi.org/10.1101/2020.07.13.198069

Sven H. Schmidt

1Department of Biochemistry, University of Kassel, 34132 Kassel, Germany

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Jui-Hung Weng

2Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA

3Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

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Phillip C. Aoto

2Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA

3Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

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Daniela Boassa

4National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093, USA

5Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA

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Sebastian Mathea

6Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany

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Steven Silletti

3Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

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Junru Hu

4National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093, USA

5Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA

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Maximilian Wallbott

1Department of Biochemistry, University of Kassel, 34132 Kassel, Germany

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Elizabeth A Komives

3Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

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Stefan Knapp

6Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany

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Friedrich W. Herberg

1Department of Biochemistry, University of Kassel, 34132 Kassel, Germany

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For correspondence: staylor@ucsd.edu

Susan S. Taylor

2Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA

3Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

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For correspondence: staylor@ucsd.edu

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Posted July 14, 2020.

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Sven H. Schmidt, Jui-Hung Weng, Phillip C. Aoto, Daniela Boassa, Sebastian Mathea, Steven Silletti, Junru Hu, Maximilian Wallbott, Elizabeth A Komives, Stefan Knapp, Friedrich W. Herberg, Susan S. Taylor

bioRxiv 2020.07.13.198069; doi: https://doi.org/10.1101/2020.07.13.198069

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