Tobacco, but not nicotine and flavor-less electronic cigarettes, induces ACE2 and immune dysregulation

Abby C. Lee; Jaideep Chakladar; Wei Tse Li; Chengyu Chen; Eric Y. Chang; Jessica Wang-Rodriguez; Weg M. Ongkeko

doi:10.1101/2020.07.13.198630

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Tobacco, but not nicotine and flavor-less electronic cigarettes, induces ACE2 and immune dysregulation

Abby C. Lee, Jaideep Chakladar, Wei Tse Li, Chengyu Chen, Eric Y. Chang, Jessica Wang-Rodriguez, Weg M. Ongkeko

doi: https://doi.org/10.1101/2020.07.13.198630

Abby C. Lee

1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA; (A.L.); (J.C.); (W.T.L.); (C.C.); (W.M.O)

2Research Service, VA San Diego Healthcare System San Diego, La Jolla, CA 92161, USA; (A.L.); (J.C.); (W.T.L.); (W.M.O)

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For correspondence: acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu chc401@ucsd.edu rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu rongkeko@health.ucsd.edu

Jaideep Chakladar

1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA; (A.L.); (J.C.); (W.T.L.); (C.C.); (W.M.O)

2Research Service, VA San Diego Healthcare System San Diego, La Jolla, CA 92161, USA; (A.L.); (J.C.); (W.T.L.); (W.M.O)

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For correspondence: acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu chc401@ucsd.edu rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu rongkeko@health.ucsd.edu

Wei Tse Li

1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA; (A.L.); (J.C.); (W.T.L.); (C.C.); (W.M.O)

2Research Service, VA San Diego Healthcare System San Diego, La Jolla, CA 92161, USA; (A.L.); (J.C.); (W.T.L.); (W.M.O)

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For correspondence: acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu chc401@ucsd.edu rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu rongkeko@health.ucsd.edu

Chengyu Chen

1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA; (A.L.); (J.C.); (W.T.L.); (C.C.); (W.M.O)

2Research Service, VA San Diego Healthcare System San Diego, La Jolla, CA 92161, USA; (A.L.); (J.C.); (W.T.L.); (W.M.O)

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For correspondence: acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu chc401@ucsd.edu rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu rongkeko@health.ucsd.edu

Eric Y. Chang

3Department of Radiology, Radiology Service, VA San Diego Healthcare System San Diego, University of California San Diego, La Jolla, CA 92093, USA;

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For correspondence: Eric.Chang2@va.gov

Jessica Wang-Rodriguez

4Department of Pathology, Pathology Service, VA San Diego Healthcare System San Diego, University of California San Diego, La Jolla, CA 92093, USA;

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For correspondence: Jessica.Wang-Rodriguez@va.gov

Weg M. Ongkeko

1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA; (A.L.); (J.C.); (W.T.L.); (C.C.); (W.M.O)

2Research Service, VA San Diego Healthcare System San Diego, La Jolla, CA 92161, USA; (A.L.); (J.C.); (W.T.L.); (W.M.O)

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For correspondence: rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu chc401@ucsd.edu rongkeko@health.ucsd.edu acl008@ucsd.edu jchaklad@ucsd.edu wtl008@ucsd.edu rongkeko@health.ucsd.edu