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PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes

C. Coulson-Gilmer, R.D. Morgan, L. Nelson, B. Barnes, J.C. McGrail, View ORCID ProfileS.S. Taylor
doi: https://doi.org/10.1101/2020.07.13.199968
C. Coulson-Gilmer
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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R.D. Morgan
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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L. Nelson
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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B. Barnes
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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J.C. McGrail
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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S.S. Taylor
1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
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  • ORCID record for S.S. Taylor
  • For correspondence: stephen.taylor@manchester.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2020.07.13.199968
History 
  • July 15, 2020.

Article Versions

  • Version 1 (July 13, 2020 - 16:16).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. C. Coulson-Gilmer1,
  2. R.D. Morgan1,
  3. L. Nelson1,
  4. B. Barnes1,
  5. J.C. McGrail1 and
  6. S.S. Taylor1,*
  1. 1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, United Kingdom
  1. ↵*Lead Contact and Corresponding Author: stephen.taylor{at}manchester.ac.uk
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Posted July 15, 2020.
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PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes
C. Coulson-Gilmer, R.D. Morgan, L. Nelson, B. Barnes, J.C. McGrail, S.S. Taylor
bioRxiv 2020.07.13.199968; doi: https://doi.org/10.1101/2020.07.13.199968
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PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes
C. Coulson-Gilmer, R.D. Morgan, L. Nelson, B. Barnes, J.C. McGrail, S.S. Taylor
bioRxiv 2020.07.13.199968; doi: https://doi.org/10.1101/2020.07.13.199968

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