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The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress

Francesco A. Servello, View ORCID ProfileJavier Apfeld
doi: https://doi.org/10.1101/2020.07.13.200634
Francesco A. Servello
Biology Department, Northeastern University, Boston, MA, 02115, USA
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Javier Apfeld
Biology Department, Northeastern University, Boston, MA, 02115, USA
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  • ORCID record for Javier Apfeld
  • For correspondence: j.apfeld@northeastern.edu
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Abstract

Cells induce conserved defense mechanisms that protect them from oxidative stress. How these defenses are regulated in multicellular organisms is incompletely understood. Using the nematode Caenorhabditis elegans, we show that the heat shock transcription factor HSF-1 protects the nematode from the oxidative stress induced by environmental peroxide. In response to a heat shock or a mild temperature increase, HSF-1 protects the nematodes from subsequent oxidative stress in a manner that depends on HSF-1’s transactivation domain. At constant temperature, HSF-1 protects the nematodes from oxidative stress independently of its transactivation domain, likely by inducing the expression of asp-4/cathepsin D and dapk-1/dapk. Thus, two distinct HSF-1-dependent processes protect C. elegans from oxidative stress.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 14, 2020.
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The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress
Francesco A. Servello, Javier Apfeld
bioRxiv 2020.07.13.200634; doi: https://doi.org/10.1101/2020.07.13.200634
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The heat shock transcription factor HSF-1 protects Caenorhabditis elegans from peroxide stress
Francesco A. Servello, Javier Apfeld
bioRxiv 2020.07.13.200634; doi: https://doi.org/10.1101/2020.07.13.200634

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