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An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization

Stéphane Pages, Nicolas Chenouard, Ronan Chéreau, Vladimir Kouskoff, Frédéric Gambino, View ORCID ProfileAnthony Holtmaat
doi: https://doi.org/10.1101/2020.07.13.200923
Stéphane Pages
1Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva, Geneva, Switzerland
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Nicolas Chenouard
2Interdiscilplinary Institute for NeuroScience (IINS), Centre Broca Nouvelle-Aquitaine, CNRS and University of Bordeaux, Bordeaux, France
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Ronan Chéreau
1Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva, Geneva, Switzerland
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Vladimir Kouskoff
2Interdiscilplinary Institute for NeuroScience (IINS), Centre Broca Nouvelle-Aquitaine, CNRS and University of Bordeaux, Bordeaux, France
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Frédéric Gambino
2Interdiscilplinary Institute for NeuroScience (IINS), Centre Broca Nouvelle-Aquitaine, CNRS and University of Bordeaux, Bordeaux, France
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  • For correspondence: anthony.holtmaat@unige.ch
Anthony Holtmaat
1Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva, Geneva, Switzerland
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  • ORCID record for Anthony Holtmaat
  • For correspondence: anthony.holtmaat@unige.ch
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ABSTRACT

The organization of sensory maps in the cerebral cortex depends on experience, which drives homeostatic and long-term synaptic plasticity of cortico-cortical circuits. In the mouse primary somatosensory cortex (S1) afferents from the higher-order, posterior medial thalamic nucleus (POm) gate synaptic plasticity in layer (L) 2/3 pyramidal neurons via disinhibition and the production of dendritic plateau potentials. Here we address whether these thalamocortically mediated responses play a role in whisker map plasticity in S1. We find that trimming all but two whiskers causes a partial fusion of the representations of the two spared whiskers, concomitantly with an increase in the occurrence of POm-driven, N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials. Blocking the plateau potentials restores the archetypical organization of the sensory map. Our results reveal a novel mechanism for experience-dependent cortical map plasticity in which higher-order thalamocortically mediated plateau potentials facilitate the fusion of normally segregated cortical representations.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 14, 2020.
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An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization
Stéphane Pages, Nicolas Chenouard, Ronan Chéreau, Vladimir Kouskoff, Frédéric Gambino, Anthony Holtmaat
bioRxiv 2020.07.13.200923; doi: https://doi.org/10.1101/2020.07.13.200923
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An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization
Stéphane Pages, Nicolas Chenouard, Ronan Chéreau, Vladimir Kouskoff, Frédéric Gambino, Anthony Holtmaat
bioRxiv 2020.07.13.200923; doi: https://doi.org/10.1101/2020.07.13.200923

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