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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Chelsea D. Painter, Bryan E. Thacker, Charles A. Glass, Anoop Narayanan, Sydney A. Majowicz, Yang Zhang, Jonathan L. Torres, Gregory J. Golden, Ryan Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, View ORCID ProfileXin Yin, Yuan Pu, Blake Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sandra L. Leibel, Summit K. Chanda, Aaron G. Schmidt, Kamil Godula, Joyce Jose, Kevin D. Corbett, View ORCID ProfileAndrew B. Ward, Aaron F. Carlin, View ORCID ProfileJeffrey D. Esko
doi: https://doi.org/10.1101/2020.07.14.201616
Thomas Mandel Clausen
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
2Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark
Daniel R. Sandoval
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Charlotte B. Spliid
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
2Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark
Jessica Pihl
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
2Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark
Chelsea D. Painter
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
3Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA
Bryan E. Thacker
4TEGA Therapeutics, Inc., 3550 General Atomics Court, G02-102, San Diego, CA 92121, USA
Charles A. Glass
4TEGA Therapeutics, Inc., 3550 General Atomics Court, G02-102, San Diego, CA 92121, USA
Anoop Narayanan
5Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA
Sydney A. Majowicz
5Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA
Yang Zhang
6Copenhagen Center for Glycomics, Department of Molecular and Cellular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
Jonathan L. Torres
7Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Gregory J. Golden
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
3Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA
Ryan Porell
8Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
Aaron F. Garretson
9Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
Logan Laubach
8Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
Jared Feldman
10Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139, USA
Xin Yin
11Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Yuan Pu
11Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Blake Hauser
10Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139, USA
Timothy M. Caradonna
10Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139, USA
Benjamin P. Kellman
12Department of Bioengineering, University of California, San Diego.
13Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
14Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA
Cameron Martino
12Department of Bioengineering, University of California, San Diego.
13Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
Philip L.S.M. Gordts
9Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
16Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA
Sandra L. Leibel
13Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
Summit K. Chanda
11Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Aaron G. Schmidt
10Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139, USA
15Department of Microbiology, Harvard Medical School, Boston, MA, 02115 USA
Kamil Godula
8Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
16Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA
Joyce Jose
5Department of Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA
Kevin D. Corbett
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Andrew B. Ward
7Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Aaron F. Carlin
9Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
Jeffrey D. Esko
1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
16Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA
Posted July 14, 2020.
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Chelsea D. Painter, Bryan E. Thacker, Charles A. Glass, Anoop Narayanan, Sydney A. Majowicz, Yang Zhang, Jonathan L. Torres, Gregory J. Golden, Ryan Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sandra L. Leibel, Summit K. Chanda, Aaron G. Schmidt, Kamil Godula, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko
bioRxiv 2020.07.14.201616; doi: https://doi.org/10.1101/2020.07.14.201616
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Chelsea D. Painter, Bryan E. Thacker, Charles A. Glass, Anoop Narayanan, Sydney A. Majowicz, Yang Zhang, Jonathan L. Torres, Gregory J. Golden, Ryan Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sandra L. Leibel, Summit K. Chanda, Aaron G. Schmidt, Kamil Godula, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko
bioRxiv 2020.07.14.201616; doi: https://doi.org/10.1101/2020.07.14.201616
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