Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots

Isabel Betegón-Putze, Josep Mercadal, Nadja Bosch, Ainoa Planas-Riverola, Mar Marquès-Bueno, Josep Vilarrasa-Blasi, David Frigola, Rebecca Corinna Burkart, Cristina Martínez, Yvonne Stahl, View ORCID ProfileSalomé Prat, Marta Ibañes, View ORCID ProfileAna I. Caño-Delgado
doi: https://doi.org/10.1101/2020.07.15.203638
Isabel Betegón-Putze
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josep Mercadal
2Departament de Matèria Condensada, Facultat de Física, Universitat de Barcelona, 08028 Barcelona, Spain
3Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nadja Bosch
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ainoa Planas-Riverola
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mar Marquès-Bueno
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josep Vilarrasa-Blasi
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
4Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Frigola
2Departament de Matèria Condensada, Facultat de Física, Universitat de Barcelona, 08028 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rebecca Corinna Burkart
5Institute for Developmental Genetics, Heinrich-Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cristina Martínez
6Department of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB), Darwin 3, Madrid E-28049, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yvonne Stahl
5Institute for Developmental Genetics, Heinrich-Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Salomé Prat
6Department of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB), Darwin 3, Madrid E-28049, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Salomé Prat
Marta Ibañes
2Departament de Matèria Condensada, Facultat de Física, Universitat de Barcelona, 08028 Barcelona, Spain
3Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ana I. Caño-Delgado
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), 08193 Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ana I. Caño-Delgado
  • For correspondence: ana.cano@cragenomica.es
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

SUMMARY

Root growth and development are essential features for plant survival and the preservation of terrestrial ecosystems. In the Arabidopsis primary root apex, stem-cell specific transcription factors BRAVO and WOX5 co-localize at the Quiescent Center (QC) cells, where they repress cell division so that these cells can act as a reservoir to replenish surrounding stem cells, yet their molecular connection remains unknown. Here, by using empirical evidence and mathematical modeling, we establish the precise regulatory and molecular interactions between BRAVO and WOX5. We found that BRAVO and WOX5 regulate each other besides forming a transcription factor complex in the QC necessary to preserve overall root growth and architecture. Our results unveil the importance of transcriptional regulatory circuits at the quiescent and stem cells to the control of organ initiation and growth of plant tissues.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted July 16, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
Isabel Betegón-Putze, Josep Mercadal, Nadja Bosch, Ainoa Planas-Riverola, Mar Marquès-Bueno, Josep Vilarrasa-Blasi, David Frigola, Rebecca Corinna Burkart, Cristina Martínez, Yvonne Stahl, Salomé Prat, Marta Ibañes, Ana I. Caño-Delgado
bioRxiv 2020.07.15.203638; doi: https://doi.org/10.1101/2020.07.15.203638
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
Isabel Betegón-Putze, Josep Mercadal, Nadja Bosch, Ainoa Planas-Riverola, Mar Marquès-Bueno, Josep Vilarrasa-Blasi, David Frigola, Rebecca Corinna Burkart, Cristina Martínez, Yvonne Stahl, Salomé Prat, Marta Ibañes, Ana I. Caño-Delgado
bioRxiv 2020.07.15.203638; doi: https://doi.org/10.1101/2020.07.15.203638

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Plant Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2409)
  • Biochemistry (4757)
  • Bioengineering (3299)
  • Bioinformatics (14579)
  • Biophysics (6588)
  • Cancer Biology (5129)
  • Cell Biology (7376)
  • Clinical Trials (138)
  • Developmental Biology (4315)
  • Ecology (6822)
  • Epidemiology (2057)
  • Evolutionary Biology (9838)
  • Genetics (7308)
  • Genomics (9467)
  • Immunology (4506)
  • Microbiology (12587)
  • Molecular Biology (4901)
  • Neuroscience (28097)
  • Paleontology (198)
  • Pathology (799)
  • Pharmacology and Toxicology (1372)
  • Physiology (1993)
  • Plant Biology (4450)
  • Scientific Communication and Education (966)
  • Synthetic Biology (1293)
  • Systems Biology (3892)
  • Zoology (717)