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A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

Ahmed O. Hassan, Natasha M. Kafai, Igor P. Dmitriev, Julie M. Fox, Brittany Smith, Ian B. Harvey, Rita E. Chen, Emma S. Winkler, Alex W. Wessel, James Brett Case, Elena Kashentseva, Broc T. McCune, Adam L. Bailey, Haiyan Zhao, Laura A. VanBlargan, Yanan Dai, Meisheng Ma, Lucas J. Adams, Swathi Shrihari, Lisa E. Gralinski, Yixuan J. Hou, Alexandra Schaefer, Arthur S. Kim, Shamus P. Keeler, Daniela Weiskopf, Ralph Baric, Michael J. Holtzman, Daved H. Fremont, David T. Curiel, View ORCID ProfileMichael S. Diamond
doi: https://doi.org/10.1101/2020.07.16.205088
Ahmed O. Hassan
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Natasha M. Kafai
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Igor P. Dmitriev
2Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Julie M. Fox
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Brittany Smith
5Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA
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Ian B. Harvey
5Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA
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Rita E. Chen
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Emma S. Winkler
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Alex W. Wessel
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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James Brett Case
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Elena Kashentseva
2Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Broc T. McCune
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Adam L. Bailey
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Haiyan Zhao
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Laura A. VanBlargan
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Yanan Dai
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Meisheng Ma
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Lucas J. Adams
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Swathi Shrihari
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Lisa E. Gralinski
9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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Yixuan J. Hou
9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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Alexandra Schaefer
9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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Arthur S. Kim
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
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Shamus P. Keeler
6Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Daniela Weiskopf
8Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA
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Ralph Baric
9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
10Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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Michael J. Holtzman
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
6Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
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Daved H. Fremont
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
5Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA
7The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
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David T. Curiel
2Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
7The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
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  • For correspondence: dcuriel@wustl.edu diamond@wusm.wustl.edu
Michael S. Diamond
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
4Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
7The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
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  • ORCID record for Michael S. Diamond
  • For correspondence: dcuriel@wustl.edu diamond@wusm.wustl.edu
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Article Information

doi 
https://doi.org/10.1101/2020.07.16.205088
History 
  • July 17, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Ahmed O. Hassan1,
  2. Natasha M. Kafai1,3,
  3. Igor P. Dmitriev2,
  4. Julie M. Fox1,
  5. Brittany Smith5,
  6. Ian B. Harvey5,
  7. Rita E. Chen1,3,
  8. Emma S. Winkler1,3,
  9. Alex W. Wessel1,3,
  10. James Brett Case1,
  11. Elena Kashentseva2,
  12. Broc T. McCune1,
  13. Adam L. Bailey3,
  14. Haiyan Zhao3,
  15. Laura A. VanBlargan1,
  16. Yanan Dai3,
  17. Meisheng Ma3,
  18. Lucas J. Adams3,
  19. Swathi Shrihari1,
  20. Lisa E. Gralinski9,
  21. Yixuan J. Hou9,
  22. Alexandra Schaefer9,
  23. Arthur S. Kim1,3,
  24. Shamus P. Keeler6,
  25. Daniela Weiskopf8,
  26. Ralph Baric9,10,
  27. Michael J. Holtzman1,6,
  28. Daved H. Fremont3,5,7,
  29. David T. Curiel2,7,* and
  30. Michael S. Diamond1,3,4,7,*
  1. 1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
  2. 2Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
  3. 3Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
  4. 4Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
  5. 5Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA
  6. 6Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
  7. 7The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
  8. 8Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA
  9. 9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  10. 10Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  1. ↵*Corresponding authors: David T. Curiel (dcuriel{at}wustl.edu) and Michael S. Diamond, M.D., Ph.D. (diamond{at}wusm.wustl.edu)
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection
Ahmed O. Hassan, Natasha M. Kafai, Igor P. Dmitriev, Julie M. Fox, Brittany Smith, Ian B. Harvey, Rita E. Chen, Emma S. Winkler, Alex W. Wessel, James Brett Case, Elena Kashentseva, Broc T. McCune, Adam L. Bailey, Haiyan Zhao, Laura A. VanBlargan, Yanan Dai, Meisheng Ma, Lucas J. Adams, Swathi Shrihari, Lisa E. Gralinski, Yixuan J. Hou, Alexandra Schaefer, Arthur S. Kim, Shamus P. Keeler, Daniela Weiskopf, Ralph Baric, Michael J. Holtzman, Daved H. Fremont, David T. Curiel, Michael S. Diamond
bioRxiv 2020.07.16.205088; doi: https://doi.org/10.1101/2020.07.16.205088
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection
Ahmed O. Hassan, Natasha M. Kafai, Igor P. Dmitriev, Julie M. Fox, Brittany Smith, Ian B. Harvey, Rita E. Chen, Emma S. Winkler, Alex W. Wessel, James Brett Case, Elena Kashentseva, Broc T. McCune, Adam L. Bailey, Haiyan Zhao, Laura A. VanBlargan, Yanan Dai, Meisheng Ma, Lucas J. Adams, Swathi Shrihari, Lisa E. Gralinski, Yixuan J. Hou, Alexandra Schaefer, Arthur S. Kim, Shamus P. Keeler, Daniela Weiskopf, Ralph Baric, Michael J. Holtzman, Daved H. Fremont, David T. Curiel, Michael S. Diamond
bioRxiv 2020.07.16.205088; doi: https://doi.org/10.1101/2020.07.16.205088

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