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Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

Justyna A. Resztak, Allison K. Farrell, Henriette E. Mair-Meijers, Adnan Alazizi, Xiaoquan Wen, Derek E. Wildman, Samuele Zilioli, Richard B. Slatcher, View ORCID ProfileRoger Pique-Regi, View ORCID ProfileFrancesca Luca
doi: https://doi.org/10.1101/2020.07.16.206912
Justyna A. Resztak
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
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Allison K. Farrell
2Department of Psychology, Miami University, Oxford, OH
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Henriette E. Mair-Meijers
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
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Adnan Alazizi
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
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Xiaoquan Wen
3Department of Biostatistics, University of Michigan, Ann Arbor, MI
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Derek E. Wildman
4College of Public Health, University of South Florida, Tampa, FL
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Samuele Zilioli
5Department of Psychology, Wayne State University, Detroit, MI
6Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI
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Richard B. Slatcher
5Department of Psychology, Wayne State University, Detroit, MI
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Roger Pique-Regi
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
7Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
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  • For correspondence: fluca@wayne.edu rpique@wayne.edu
Francesca Luca
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
7Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
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  • ORCID record for Francesca Luca
  • For correspondence: fluca@wayne.edu rpique@wayne.edu
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Abstract

Social interactions and the overall psychosocial environment have a demonstrated impact on health, particularly for people living in disadvantaged urban areas. Here we investigated the effect of psychosocial experiences on gene expression in peripheral blood immune cells of children with asthma in Metro Detroit. Using RNA-sequencing and a new machine learning approach, we identified transcriptional signatures of 20 variables including psychosocial factors, blood cell composition and asthma symptoms. Importantly, we found 174 genes associated with asthma that are regulated by psychosocial factors, and 349 significant gene-environment interactions for gene expression levels. These results demonstrate that immune gene expression mediates the link between negative psychosocial experiences and asthma risk.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 01, 2020.
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Psychosocial experiences modulate asthma-associated genes through gene-environment interactions
Justyna A. Resztak, Allison K. Farrell, Henriette E. Mair-Meijers, Adnan Alazizi, Xiaoquan Wen, Derek E. Wildman, Samuele Zilioli, Richard B. Slatcher, Roger Pique-Regi, Francesca Luca
bioRxiv 2020.07.16.206912; doi: https://doi.org/10.1101/2020.07.16.206912
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Psychosocial experiences modulate asthma-associated genes through gene-environment interactions
Justyna A. Resztak, Allison K. Farrell, Henriette E. Mair-Meijers, Adnan Alazizi, Xiaoquan Wen, Derek E. Wildman, Samuele Zilioli, Richard B. Slatcher, Roger Pique-Regi, Francesca Luca
bioRxiv 2020.07.16.206912; doi: https://doi.org/10.1101/2020.07.16.206912

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