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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

View ORCID ProfileAubin Moutal, View ORCID ProfileLaurent F. Martin, View ORCID ProfileLisa Boinon, View ORCID ProfileKimberly Gomez, View ORCID ProfileDongzhi Ran, Yuan Zhou, View ORCID ProfileHarrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, View ORCID ProfileSamantha Perez-Miller, Amol Patwardhan, Mohab M. Ibrahim, View ORCID ProfileRajesh Khanna
doi: https://doi.org/10.1101/2020.07.17.209288
Aubin Moutal
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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  • ORCID record for Aubin Moutal
Laurent F. Martin
2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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  • ORCID record for Laurent F. Martin
Lisa Boinon
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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  • ORCID record for Lisa Boinon
Kimberly Gomez
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Dongzhi Ran
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Yuan Zhou
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Harrison J. Stratton
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Song Cai
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Shizhen Luo
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Kerry Beth Gonzalez
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Samantha Perez-Miller
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Amol Patwardhan
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Mohab M. Ibrahim
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America
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Rajesh Khanna
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
3Center for Innovation in Brain Sciences, University of Arizona, Tucson, Arizona 85721, United States of America
4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America
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  • For correspondence: rkhanna@arizona.edu
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Article Information

doi 
https://doi.org/10.1101/2020.07.17.209288
History 
  • July 18, 2020.

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  • Version 2 (August 24, 2020 - 16:55).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Aubin Moutal1,
  2. Laurent F. Martin2,†,
  3. Lisa Boinon1,†,
  4. Kimberly Gomez1,†,
  5. Dongzhi Ran1,†,
  6. Yuan Zhou1,†,
  7. Harrison J. Stratton1,
  8. Song Cai1,
  9. Shizhen Luo1,
  10. Kerry Beth Gonzalez1,
  11. Samantha Perez-Miller1,2,
  12. Amol Patwardhan1,2,4,
  13. Mohab M. Ibrahim1,2,4 and
  14. Rajesh Khanna1,2,3,4,*
  1. 1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
  2. 2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America
  3. 3Center for Innovation in Brain Sciences, University of Arizona, Tucson, Arizona 85721, United States of America
  4. 4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America
  1. ↵*Correspondence to: Dr. Rajesh Khanna, Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ 85724, USA Office phone: (520) 626-4281; Fax: (520) 626-2204; Email: rkhanna{at}arizona.edu
  1. ↵† Contributed equally

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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
Aubin Moutal, Laurent F. Martin, Lisa Boinon, Kimberly Gomez, Dongzhi Ran, Yuan Zhou, Harrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, Samantha Perez-Miller, Amol Patwardhan, Mohab M. Ibrahim, Rajesh Khanna
bioRxiv 2020.07.17.209288; doi: https://doi.org/10.1101/2020.07.17.209288
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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
Aubin Moutal, Laurent F. Martin, Lisa Boinon, Kimberly Gomez, Dongzhi Ran, Yuan Zhou, Harrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, Samantha Perez-Miller, Amol Patwardhan, Mohab M. Ibrahim, Rajesh Khanna
bioRxiv 2020.07.17.209288; doi: https://doi.org/10.1101/2020.07.17.209288

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