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Generalized Hidden Markov Models for Phylogenetic Comparative Datasets

James D. Boyko, Jeremy M. Beaulieu
doi: https://doi.org/10.1101/2020.07.18.209874
James D. Boyko
1Department of Biological Sciences, University of Arkansas, Fayetteville, AR, 72701, USA
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  • For correspondence: jboyko@uark.edu
Jeremy M. Beaulieu
1Department of Biological Sciences, University of Arkansas, Fayetteville, AR, 72701, USA
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Abstract

  1. Hidden Markov models (HMM) have emerged as an important tool for understanding the evolution of characters that take on discrete states. Their flexibility and biological sensibility make them appealing for many phylogenetic comparative applications.

  2. Previously available packages placed unnecessary limits on the number of observed and hidden states that can be considered when estimating transition rates and inferring ancestral states on a phylogeny.

  3. To address these issues, we expanded the capabilities of the R package corHMM to handle n-state and n-character problems and provide users with a streamlined set of functions to create custom HMMs for any biological question of arbitrary complexity.

  4. We show that increasing the number of observed states increases the accuracy of ancestral state reconstruction. We also explore the conditions for when an HMM is most effective, finding that an HMM outperforms a Markov model when the degree of rate heterogeneity is moderate to high.

  5. Finally, we demonstrate the importance of these generalizations by reconstructing the morphology of the ancestral angiosperm flower. Exactly opposite to previous results, we find the most likely state to be a spiral perianth, spiral androecium, whorled gynoecium. The difference between our analysis and previous studies was that our modeling allowed for the correlated evolution of several flower characters.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 18, 2020.
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Generalized Hidden Markov Models for Phylogenetic Comparative Datasets
James D. Boyko, Jeremy M. Beaulieu
bioRxiv 2020.07.18.209874; doi: https://doi.org/10.1101/2020.07.18.209874
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Generalized Hidden Markov Models for Phylogenetic Comparative Datasets
James D. Boyko, Jeremy M. Beaulieu
bioRxiv 2020.07.18.209874; doi: https://doi.org/10.1101/2020.07.18.209874

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