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Neurometabolite Mapping Highlights Elevated Myo-inositol Profiles within the Developing Brain in Down Syndrome

View ORCID ProfilePrachi A. Patkee, View ORCID ProfileAna A. Baburamani, View ORCID ProfileKatherine R. Long, View ORCID ProfileRalica Dimitrova, View ORCID ProfileJudit Ciarrusta, Joanna Allsop, View ORCID ProfileEmer Hughes, View ORCID ProfileJohanna Kangas, View ORCID ProfileGrainne McAlonan, View ORCID ProfileMary A. Rutherford
doi: https://doi.org/10.1101/2020.07.20.211805
Prachi A. Patkee
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
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Ana A. Baburamani
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
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Katherine R. Long
2Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE1 1UL, UK
3MRC Centre for Neurodevelopmental Disorders, King’s College London, SE1 1UL, UK
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Ralica Dimitrova
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
4Department of Forensic and Neurodevelopmental Science, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AB, UK
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Judit Ciarrusta
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
4Department of Forensic and Neurodevelopmental Science, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AB, UK
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Joanna Allsop
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
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Emer Hughes
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
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Johanna Kangas
4Department of Forensic and Neurodevelopmental Science, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AB, UK
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Grainne McAlonan
4Department of Forensic and Neurodevelopmental Science, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AB, UK
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Mary A. Rutherford
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
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  • For correspondence: prachi.patkee@kcl.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2020.07.20.211805
History 
  • July 20, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Prachi A. Patkee1,
  2. Ana A. Baburamani1,
  3. Katherine R. Long2,3,
  4. Ralica Dimitrova1,4,
  5. Judit Ciarrusta1,4,
  6. Joanna Allsop1,
  7. Emer Hughes1,
  8. Johanna Kangas4,
  9. Grainne McAlonan4 and
  10. Mary A. Rutherford1,*
  1. 1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
  2. 2Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE1 1UL, UK
  3. 3MRC Centre for Neurodevelopmental Disorders, King’s College London, SE1 1UL, UK
  4. 4Department of Forensic and Neurodevelopmental Science, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, SE5 8AB, UK
  1. ↵*Corresponding author email: prachi.patkee{at}kcl.ac.uk
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Neurometabolite Mapping Highlights Elevated Myo-inositol Profiles within the Developing Brain in Down Syndrome
Prachi A. Patkee, Ana A. Baburamani, Katherine R. Long, Ralica Dimitrova, Judit Ciarrusta, Joanna Allsop, Emer Hughes, Johanna Kangas, Grainne McAlonan, Mary A. Rutherford
bioRxiv 2020.07.20.211805; doi: https://doi.org/10.1101/2020.07.20.211805
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Neurometabolite Mapping Highlights Elevated Myo-inositol Profiles within the Developing Brain in Down Syndrome
Prachi A. Patkee, Ana A. Baburamani, Katherine R. Long, Ralica Dimitrova, Judit Ciarrusta, Joanna Allsop, Emer Hughes, Johanna Kangas, Grainne McAlonan, Mary A. Rutherford
bioRxiv 2020.07.20.211805; doi: https://doi.org/10.1101/2020.07.20.211805

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