Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety

Nikolaos Tataridas-Pallas, Maximillian Thompson, Alexander Howard, Ian Brown, Marina Ezcurra, Ziyun Wu, Timo Keurten, Isabel Goncalves Silva, T. Keith Blackwell, View ORCID ProfileJennifer Tullet
doi: https://doi.org/10.1101/2020.07.21.213504
Nikolaos Tataridas-Pallas
1School of Biosciences, University of Kent, Canterbury, CT2 7NZ, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maximillian Thompson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander Howard
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Brown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marina Ezcurra
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ziyun Wu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timo Keurten
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabel Goncalves Silva
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Keith Blackwell
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer Tullet
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jennifer Tullet
  • For correspondence: j.m.a.tullet@kent.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism and respiration, because can mediate the increased lifespan incurred by dietary restriction. We show that actually SKN-1B is not essential for dietary restriction longevity and instead, controls a variety of food-related behaviours. It acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵† Joint first authors

  • Summary and introduction updated to clarify the role of SKN-1B in mediating dietary restriction incurred longevity; and author email address corrected.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted July 27, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety
Nikolaos Tataridas-Pallas, Maximillian Thompson, Alexander Howard, Ian Brown, Marina Ezcurra, Ziyun Wu, Timo Keurten, Isabel Goncalves Silva, T. Keith Blackwell, Jennifer Tullet
bioRxiv 2020.07.21.213504; doi: https://doi.org/10.1101/2020.07.21.213504
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety
Nikolaos Tataridas-Pallas, Maximillian Thompson, Alexander Howard, Ian Brown, Marina Ezcurra, Ziyun Wu, Timo Keurten, Isabel Goncalves Silva, T. Keith Blackwell, Jennifer Tullet
bioRxiv 2020.07.21.213504; doi: https://doi.org/10.1101/2020.07.21.213504

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genetics
  • Animal Behavior and Cognition
Subject Areas
All Articles
  • Animal Behavior and Cognition (4395)
  • Biochemistry (9613)
  • Bioengineering (7110)
  • Bioinformatics (24911)
  • Biophysics (12642)
  • Cancer Biology (9978)
  • Cell Biology (14375)
  • Clinical Trials (138)
  • Developmental Biology (7967)
  • Ecology (12131)
  • Epidemiology (2067)
  • Evolutionary Biology (16007)
  • Genetics (10937)
  • Genomics (14762)
  • Immunology (9886)
  • Microbiology (23701)
  • Molecular Biology (9491)
  • Neuroscience (50960)
  • Paleontology (370)
  • Pathology (1544)
  • Pharmacology and Toxicology (2688)
  • Physiology (4031)
  • Plant Biology (8677)
  • Scientific Communication and Education (1512)
  • Synthetic Biology (2402)
  • Systems Biology (6446)
  • Zoology (1346)