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Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

View ORCID ProfileE.I. Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S.L. Smith, E.R. Anderson, T. Prince, G.T. Patterson, E. Lorusso, M.S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, A. Stranieri, V. Martella, F. Solari Basano, V.R. Barrs, A.D. Radford, U. Agrimi, View ORCID ProfileG. L. Hughes, S. Paltrinieri, View ORCID ProfileN. Decaro
doi: https://doi.org/10.1101/2020.07.21.214346
E.I. Patterson
1Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
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  • ORCID record for E.I. Patterson
G. Elia
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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A. Grassi
3I-VET srl, Laboratorio di Analisi Veterinarie, Via Ettore Majorana, 10 - 25020 Flero (BS), Italy
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A. Giordano
4Department of Veterinary Medicine, University of Milan; Veterinary Teaching Hospital, University of Milan, Via dell’Università 6, 26900 Lodi, Italy
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C. Desario
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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M. Medardo
5La Vallonèa Veterinary Diagnostic Laboratory, via G. Sirtori 9, 20017 Passirana di Rho (MI), Italy
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S.L. Smith
6Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK
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E.R. Anderson
1Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
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T. Prince
7NIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool UK
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G.T. Patterson
6Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK
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E. Lorusso
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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M.S. Lucente
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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G. Lanave
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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S. Lauzi
4Department of Veterinary Medicine, University of Milan; Veterinary Teaching Hospital, University of Milan, Via dell’Università 6, 26900 Lodi, Italy
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U. Bonfanti
5La Vallonèa Veterinary Diagnostic Laboratory, via G. Sirtori 9, 20017 Passirana di Rho (MI), Italy
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A. Stranieri
4Department of Veterinary Medicine, University of Milan; Veterinary Teaching Hospital, University of Milan, Via dell’Università 6, 26900 Lodi, Italy
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V. Martella
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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F. Solari Basano
8Arcoblu s.r.l., via Alessandro Milesi 5, 20133 Milan, Italy
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V.R. Barrs
9City University’s Jockey Club College of Veterinary Medicine and Life Sciences, 5/F, Block 1A, To Yuen Building, 31 To Yuen Street, Kowloon, Hong Kong
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A.D. Radford
6Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK
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U. Agrimi
10Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy
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G. L. Hughes
1Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
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S. Paltrinieri
4Department of Veterinary Medicine, University of Milan; Veterinary Teaching Hospital, University of Milan, Via dell’Università 6, 26900 Lodi, Italy
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N. Decaro
2Department of Veterinary Medicine, University of Bari Aldo Moro, Strada Prov. per Casamassima Km 3, 70010Valenzano (BA), Italy
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  • For correspondence: nicola.decaro@uniba.it
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Abstract

SARS-CoV-2 originated in animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here we report a large-scale study to assess SARS-CoV-2 infection in 817 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.4% of dogs and 3.9% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

One Sentence Summary SARS-CoV-2 antibodies in pets from Italy.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 23, 2020.
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Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy
E.I. Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S.L. Smith, E.R. Anderson, T. Prince, G.T. Patterson, E. Lorusso, M.S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, A. Stranieri, V. Martella, F. Solari Basano, V.R. Barrs, A.D. Radford, U. Agrimi, G. L. Hughes, S. Paltrinieri, N. Decaro
bioRxiv 2020.07.21.214346; doi: https://doi.org/10.1101/2020.07.21.214346
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Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy
E.I. Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S.L. Smith, E.R. Anderson, T. Prince, G.T. Patterson, E. Lorusso, M.S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, A. Stranieri, V. Martella, F. Solari Basano, V.R. Barrs, A.D. Radford, U. Agrimi, G. L. Hughes, S. Paltrinieri, N. Decaro
bioRxiv 2020.07.21.214346; doi: https://doi.org/10.1101/2020.07.21.214346

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