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The roles of history, chance, and natural selection in the evolution of antibiotic resistance

View ORCID ProfileAlfonso Santos-Lopez, View ORCID ProfileChristopher W. Marshall, View ORCID ProfileAllison L. Welp, View ORCID ProfileCaroline Turner, View ORCID ProfileJavier Rasero, View ORCID ProfileVaughn S. Cooper
doi: https://doi.org/10.1101/2020.07.22.216465
Alfonso Santos-Lopez
1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Christopher W. Marshall
1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Allison L. Welp
1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Caroline Turner
1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Javier Rasero
4Department of Psychology. Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
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Vaughn S. Cooper
1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
2Microbial Genome Sequencing Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
3Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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  • For correspondence: vaughn.cooper@pitt.edu
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Article Information

doi 
https://doi.org/10.1101/2020.07.22.216465
History 
  • July 22, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Alfonso Santos-Lopez1,*,
  2. Christopher W. Marshall1,&,*,
  3. Allison L. Welp1,
  4. Caroline Turner1,#,
  5. Javier Rasero4 and
  6. Vaughn S. Cooper1,2,3,#
  1. 1Department of Microbiology and Molecular Genetics, and Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  2. 2Microbial Genome Sequencing Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  3. 3Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  4. 4Department of Psychology. Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
  1. ↵#Corresponding author; email: vaughn.cooper{at}pitt.edu
  1. ↵* A.S-L. and C.W.M. contributed equally to this manuscript

  • ↵& Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA

  • ↵# Department of Biology, Loyola University Chicago, Chicago, Illinois, USA

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Posted July 22, 2020.
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The roles of history, chance, and natural selection in the evolution of antibiotic resistance
Alfonso Santos-Lopez, Christopher W. Marshall, Allison L. Welp, Caroline Turner, Javier Rasero, Vaughn S. Cooper
bioRxiv 2020.07.22.216465; doi: https://doi.org/10.1101/2020.07.22.216465
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The roles of history, chance, and natural selection in the evolution of antibiotic resistance
Alfonso Santos-Lopez, Christopher W. Marshall, Allison L. Welp, Caroline Turner, Javier Rasero, Vaughn S. Cooper
bioRxiv 2020.07.22.216465; doi: https://doi.org/10.1101/2020.07.22.216465

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