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A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation
View ORCID ProfileJenny Ostrop, View ORCID ProfileRosalie Zwiggelaar, View ORCID ProfileMarianne Terndrup Pedersen, View ORCID ProfileFrançois Gerbe, View ORCID ProfileKorbinian Bösl, View ORCID ProfileHåvard T. Lindholm, View ORCID ProfileAlberto Díez-Sánchez, View ORCID ProfileNaveen Parmar, View ORCID ProfileSilke Radetzki, Jens Peter von Kries, View ORCID ProfilePhilippe Jay, View ORCID ProfileKim B. Jensen, View ORCID ProfileCheryl Arrowsmith, View ORCID ProfileMenno J. Oudhoff
doi: https://doi.org/10.1101/2020.07.23.217414
Jenny Ostrop
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Rosalie Zwiggelaar
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Marianne Terndrup Pedersen
2BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N, Denmark
3Novo Nordisk Foundation Center for Stem Cell Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark
François Gerbe
4Cancer Biology Department, Institute of Functional Genomics, University of Montpellier, France
Korbinian Bösl
5Computational Biological Unit, Department of Informatics, University of Bergen, Norway
Håvard T. Lindholm
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Alberto Díez-Sánchez
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Naveen Parmar
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Silke Radetzki
6Screening Unit, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany
Jens Peter von Kries
6Screening Unit, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany
Philippe Jay
4Cancer Biology Department, Institute of Functional Genomics, University of Montpellier, France
Kim B. Jensen
2BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N, Denmark
3Novo Nordisk Foundation Center for Stem Cell Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark
Cheryl Arrowsmith
7Structural Genomics Consortium, University of Toronto, Toronto, Canada
8Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
9Department of Medical Biophysics, University of Toronto, Toronto, Canada
Menno J. Oudhoff
1CEMIR – Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Posted December 11, 2020.
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation
Jenny Ostrop, Rosalie Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim B. Jensen, Cheryl Arrowsmith, Menno J. Oudhoff
bioRxiv 2020.07.23.217414; doi: https://doi.org/10.1101/2020.07.23.217414
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation
Jenny Ostrop, Rosalie Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim B. Jensen, Cheryl Arrowsmith, Menno J. Oudhoff
bioRxiv 2020.07.23.217414; doi: https://doi.org/10.1101/2020.07.23.217414
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