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CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation

Brien K. Haun, Chih-Yun Lai, Caitlin A. Williams, Teri Ann Wong, Michael M. Lieberman, Laurent Pessaint, Hanne Andersen-Elyard, Axel T. Lehrer
doi: https://doi.org/10.1101/2020.07.24.220715
Brien K. Haun
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
2Cell and Molecular Biology Graduate Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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Chih-Yun Lai
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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Caitlin A. Williams
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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Teri Ann Wong
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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Michael M. Lieberman
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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Laurent Pessaint
3BIOQUAL, Inc., Rockville, MD.
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Hanne Andersen-Elyard
3BIOQUAL, Inc., Rockville, MD.
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Axel T. Lehrer
1Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
2Cell and Molecular Biology Graduate Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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  • For correspondence: lehrer@hawaii.edu
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ABSTRACT

The current COVID-19 pandemic has claimed hundreds of thousands of lives and its causative agent, SARS-CoV-2, has infected millions, globally. The highly contagious nature of this respiratory virus has spurred massive global efforts to develop vaccines at record speeds. In addition to enhanced immunogen delivery, adjuvants may greatly impact protective efficacy of a SARS-CoV-2 vaccine. To investigate adjuvant suitability, we formulated protein subunit vaccines consisting of the recombinant S1 domain of SARS-CoV-2 Spike protein alone or in combination with either CoVaccine HT™ or Alhydrogel. CoVaccine HT™ induced high titres of antigen-binding IgG after a single dose, facilitated affinity maturation and class switching to a greater extent than Alhydrogel and elicited potent cell-mediated immunity as well as virus neutralising antibody titres. Data presented here suggests that adjuvantation with CoVaccine HT™ can rapidly induce a comprehensive and protective immune response to SARS-CoV-2.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted July 26, 2020.
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CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation
Brien K. Haun, Chih-Yun Lai, Caitlin A. Williams, Teri Ann Wong, Michael M. Lieberman, Laurent Pessaint, Hanne Andersen-Elyard, Axel T. Lehrer
bioRxiv 2020.07.24.220715; doi: https://doi.org/10.1101/2020.07.24.220715
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CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation
Brien K. Haun, Chih-Yun Lai, Caitlin A. Williams, Teri Ann Wong, Michael M. Lieberman, Laurent Pessaint, Hanne Andersen-Elyard, Axel T. Lehrer
bioRxiv 2020.07.24.220715; doi: https://doi.org/10.1101/2020.07.24.220715

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