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Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains

Tianjia Zhu, Qinmu Peng, Austin Ouyang, Hao Huang
doi: https://doi.org/10.1101/2020.07.25.221093
Tianjia Zhu
1Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
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Qinmu Peng
1Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Austin Ouyang
4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, TX, USA
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Hao Huang
1Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, TX, USA
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  • For correspondence: huangh6@email.chop.edu
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Abstract

Purpose To investigate the neuroanatomical underpinning of healthy macaque brain cortical microstructure measured by diffusion kurtosis imaging (DKI) which characterizes non-Gaussian water diffusion.

Methods High-resolution DKI was acquired from 6 postmortem macaque brains. Neurofilament density (ND) was quantified based on structure tensor from neurofilament histological images of a different macaque brain sample. After alignment of DKI-derived mean kurtosis (MK) maps to the histological images, MK and histology-based ND were measured at corresponding regions of interests characterized by distinguished cortical MK values in the prefrontal/precentral-postcentral and temporal cortices. Pearson correlation was performed to test significant correlation between these cortical MK and ND measurements.

Results Heterogeneity of cortical MK across different cortical regions was revealed, with significantly and consistently higher MK measurements in the prefrontal/precentral-postcentral cortex compared to those in the temporal cortex across all 6 scanned macaque brains. Corresponding higher ND measurements in the prefrontal/precentral-postcentral cortex than in the temporal cortex were also found. The heterogeneity of cortical MK is associated with heterogeneity of histology-based ND measurements, with significant correlation between cortical MK and corresponding ND measurements (P <0.005).

Conclusion These findings suggested that DKI-derived MK can potentially be an effective noninvasive biomarker quantifying underlying neuroanatomical complexity inside the cerebral cortical mantle for clinical and neuroscientific research.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://github.com/ritaz0904/DK_fitting

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 26, 2020.
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Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains
Tianjia Zhu, Qinmu Peng, Austin Ouyang, Hao Huang
bioRxiv 2020.07.25.221093; doi: https://doi.org/10.1101/2020.07.25.221093
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Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains
Tianjia Zhu, Qinmu Peng, Austin Ouyang, Hao Huang
bioRxiv 2020.07.25.221093; doi: https://doi.org/10.1101/2020.07.25.221093

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