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De novo designed receptor transmembrane domains enhance CAR-T cell cytotoxicity and attenuate cytokine release
Assaf Elazar, Nicholas J. Chandler, Ashleigh S. Davey, Jonathan Y. Weinstein, Julie V. Nguyen, Raphael Trenker, Misty R. Jenkins, Melissa J. Call, Matthew E. Call, View ORCID ProfileSarel J. Fleishman
doi: https://doi.org/10.1101/2020.07.26.221598
Assaf Elazar
1Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Nicholas J. Chandler
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
Ashleigh S. Davey
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
Jonathan Y. Weinstein
1Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Julie V. Nguyen
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Raphael Trenker
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
Misty R. Jenkins
3Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
5La Trobe Institute of Molecular Science, La Trobe University, Bundoora, Victoria 3083, Australia
Melissa J. Call
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
Matthew E. Call
2Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
4Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia
Sarel J. Fleishman
1Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Article usage
Posted July 26, 2020.
De novo designed receptor transmembrane domains enhance CAR-T cell cytotoxicity and attenuate cytokine release
Assaf Elazar, Nicholas J. Chandler, Ashleigh S. Davey, Jonathan Y. Weinstein, Julie V. Nguyen, Raphael Trenker, Misty R. Jenkins, Melissa J. Call, Matthew E. Call, Sarel J. Fleishman
bioRxiv 2020.07.26.221598; doi: https://doi.org/10.1101/2020.07.26.221598
De novo designed receptor transmembrane domains enhance CAR-T cell cytotoxicity and attenuate cytokine release
Assaf Elazar, Nicholas J. Chandler, Ashleigh S. Davey, Jonathan Y. Weinstein, Julie V. Nguyen, Raphael Trenker, Misty R. Jenkins, Melissa J. Call, Matthew E. Call, Sarel J. Fleishman
bioRxiv 2020.07.26.221598; doi: https://doi.org/10.1101/2020.07.26.221598
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