Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Fadi Jacob; Sarshan R. Pather; Wei-Kai Huang; Samuel Zheng Hao Wong; Haowen Zhou; Feng Zhang; Beatrice Cubitt; Catherine Z. Chen; Miao Xu; Manisha Pradhan; Daniel Y. Zhang; Wei Zheng; Anne G. Bang; Hongjun Song; Juan Carlos de a Torre; Guo-li Ming

doi:10.1101/2020.07.28.225151

New Results

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

View ORCID ProfileFadi Jacob, Sarshan R. Pather, Wei-Kai Huang, Samuel Zheng Hao Wong, Haowen Zhou, Feng Zhang, Beatrice Cubitt, Catherine Z. Chen, Miao Xu, Manisha Pradhan, Daniel Y. Zhang, Wei Zheng, Anne G. Bang, Hongjun Song, Juan Carlos de a Torre, Guo-li Ming

doi: https://doi.org/10.1101/2020.07.28.225151

Fadi Jacob

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

2The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

3Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fadi Jacob

Sarshan R. Pather

4Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wei-Kai Huang

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

5Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Samuel Zheng Hao Wong

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

6Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Haowen Zhou

7Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Feng Zhang

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Beatrice Cubitt

8Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Catherine Z. Chen

9National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Miao Xu

9National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Manisha Pradhan

9National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Daniel Y. Zhang

10Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wei Zheng

9National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anne G. Bang

7Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: abang@sbpdiscovery.org shongjun@pennmedicine.upenn.edu juanct@scripps.edu gming@pennmedicine.upenn.edu

Hongjun Song

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

11Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

12Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

13The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: abang@sbpdiscovery.org shongjun@pennmedicine.upenn.edu juanct@scripps.edu gming@pennmedicine.upenn.edu

Juan Carlos de a Torre

8Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: abang@sbpdiscovery.org shongjun@pennmedicine.upenn.edu juanct@scripps.edu gming@pennmedicine.upenn.edu

Guo-li Ming

1Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

11Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

12Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

14Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: abang@sbpdiscovery.org shongjun@pennmedicine.upenn.edu juanct@scripps.edu gming@pennmedicine.upenn.edu

Abstract
Full Text
Info/History
Metrics
Preview PDF

Article usage

Article usage: July 2020 to March 2021

	Abstract	Full	Pdf
Jul 2020	1197	9	290
Aug 2020	1133	159	576
Sep 2020	544	95	252
Oct 2020	331	65	138
Nov 2020	215	58	91
Dec 2020	159	47	91
Jan 2021	189	79	72
Feb 2021	129	32	35
Mar 2021	6	0	2

View the discussion thread.

PreviousNext

Posted July 28, 2020.

Download PDF

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Fadi Jacob, Sarshan R. Pather, Wei-Kai Huang, Samuel Zheng Hao Wong, Haowen Zhou, Feng Zhang, Beatrice Cubitt, Catherine Z. Chen, Miao Xu, Manisha Pradhan, Daniel Y. Zhang, Wei Zheng, Anne G. Bang, Hongjun Song, Juan Carlos de a Torre, Guo-li Ming

bioRxiv 2020.07.28.225151; doi: https://doi.org/10.1101/2020.07.28.225151

Share This Article: