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Preferential activation of the posterior Default-Mode Network with sequentially predictable task switches

View ORCID ProfileGarazi Araña-Oiarbide, View ORCID ProfileRichard E. Daws, View ORCID ProfileRomy Lorenz, View ORCID ProfileInes R. Violante, View ORCID ProfileAdam Hampshire
doi: https://doi.org/10.1101/2020.07.29.223180
Garazi Araña-Oiarbide
1Computational, Cognitive and Clinical Neuroscience Laboratory, Department of Medicine, Imperial College London, UK
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  • For correspondence: ga418@ic.ac.uk
Richard E. Daws
1Computational, Cognitive and Clinical Neuroscience Laboratory, Department of Medicine, Imperial College London, UK
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Romy Lorenz
2MRC Cognition and Brain Sciences Unit, University of Cambridge, UK
3The Poldrack Lab, Stanford University, US
4Department of Neurophysics, Max-Planck Institute for Human Cognitive and Brain Sciences, Germany
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Ines R. Violante
1Computational, Cognitive and Clinical Neuroscience Laboratory, Department of Medicine, Imperial College London, UK
5School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, UK
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Adam Hampshire
1Computational, Cognitive and Clinical Neuroscience Laboratory, Department of Medicine, Imperial College London, UK
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Abstract

The default-mode network (DMN) has been primarily associated with internally-directed and self-relevant cognition. This perspective is expanding to recognise its importance in executive behaviours like switching. We investigated the effect different task-switching manipulations have on DMN activation in two studies with novel fMRI paradigms. In the first study, the paradigm manipulated visual discriminability, visuo-perceptual distance and sequential predictability during switching. Increased posterior cingulate/precuneus (PCC/PrCC) activity was evident during switching; critically, this was strongest when the occurrence of the switch was predictable. In the second study, we sought to replicate and further investigate this switch-related effect with a fully factorial design manipulating sequential, spatial and visual-feature predictability. Whole-brain analysis again identified a PCC/PrCC-centred cluster that was more active for sequentially predictable versus unpredictable switches, but not for the other predictability dimensions. We propose PCC/PrCC DMN subregions may play a prominent executive role in mapping the sequential structure of complex tasks.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* ga418{at}imperial.co.uk (GAO), a.hampshire{at}imperial.ac.uk (AH)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted July 29, 2020.
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Preferential activation of the posterior Default-Mode Network with sequentially predictable task switches
Garazi Araña-Oiarbide, Richard E. Daws, Romy Lorenz, Ines R. Violante, Adam Hampshire
bioRxiv 2020.07.29.223180; doi: https://doi.org/10.1101/2020.07.29.223180
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Preferential activation of the posterior Default-Mode Network with sequentially predictable task switches
Garazi Araña-Oiarbide, Richard E. Daws, Romy Lorenz, Ines R. Violante, Adam Hampshire
bioRxiv 2020.07.29.223180; doi: https://doi.org/10.1101/2020.07.29.223180

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