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Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain

Emilia A. Gaviglio, View ORCID ProfileJavier M. Peralta Ramos, Daniela S. Arroyo, View ORCID ProfileClaudio Bussi, Pablo Iribarren, Maria C. Rodriguez-Galan
doi: https://doi.org/10.1101/2020.07.30.228098
Emilia A. Gaviglio
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigación en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina
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Javier M. Peralta Ramos
2Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel
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  • ORCID record for Javier M. Peralta Ramos
Daniela S. Arroyo
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigación en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina
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Claudio Bussi
3The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK
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Pablo Iribarren
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigación en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina
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  • For correspondence: piribarr@fcq.unc.edu.ar
Maria C. Rodriguez-Galan
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigación en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina
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Article Information

doi 
https://doi.org/10.1101/2020.07.30.228098
History 
  • July 30, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Emilia A. Gaviglio1,*,
  2. Javier M. Peralta Ramos2,*,
  3. Daniela S. Arroyo1,
  4. Claudio Bussi3,
  5. Pablo Iribarren1,#,† and
  6. Maria C. Rodriguez-Galan1,#
  1. 1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Centro de Investigación en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina
  2. 2Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel
  3. 3The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK
  1. ↵†Correspondence should be addressed to Pablo Iribarren (piribarr{at}fcq.unc.edu.ar)
  1. ↵* These authors have equally contributed to this work.

  2. ↵# These authors have equally contributed to this work.

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Posted July 30, 2020.
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Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain
Emilia A. Gaviglio, Javier M. Peralta Ramos, Daniela S. Arroyo, Claudio Bussi, Pablo Iribarren, Maria C. Rodriguez-Galan
bioRxiv 2020.07.30.228098; doi: https://doi.org/10.1101/2020.07.30.228098
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Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain
Emilia A. Gaviglio, Javier M. Peralta Ramos, Daniela S. Arroyo, Claudio Bussi, Pablo Iribarren, Maria C. Rodriguez-Galan
bioRxiv 2020.07.30.228098; doi: https://doi.org/10.1101/2020.07.30.228098

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