Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

Rafi Kohen; Katherine T. Baldwin; Patricia M. Garay; Takao Tsukahara; Alex Chen; Corey G. Flynn; Craig Johnson; Xiao-Feng Zhao; Michael A. Sutton; Shigeki Iwase; Roman J. Giger

doi:10.1101/2020.07.30.229443

New Results

Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

View ORCID ProfileRafi Kohen, View ORCID ProfileKatherine T. Baldwin, Patricia M. Garay, Takao Tsukahara, Alex Chen, Corey G. Flynn, Craig Johnson, View ORCID ProfileXiao-Feng Zhao, Michael A. Sutton, Shigeki Iwase, View ORCID ProfileRoman J. Giger

doi: https://doi.org/10.1101/2020.07.30.229443

Rafi Kohen

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rafi Kohen

Katherine T. Baldwin

2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Katherine T. Baldwin

Patricia M. Garay

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

3Deparment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Takao Tsukahara

3Deparment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2200

4Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-2200

5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alex Chen

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

4Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-2200

5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Corey G. Flynn

6School of Kinesiology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Craig Johnson

2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xiao-Feng Zhao

2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xiao-Feng Zhao

Michael A. Sutton

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

4Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-2200

5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shigeki Iwase

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

3Deparment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Roman J. Giger

1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109-2200

2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2200

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Roman J. Giger
For correspondence: rgiger@umich.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Supplemental Information[supplements/229443_file07.pdf]

View the discussion thread.

PreviousNext

Posted July 30, 2020.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

Rafi Kohen, Katherine T. Baldwin, Patricia M. Garay, Takao Tsukahara, Alex Chen, Corey G. Flynn, Craig Johnson, Xiao-Feng Zhao, Michael A. Sutton, Shigeki Iwase, Roman J. Giger

bioRxiv 2020.07.30.229443; doi: https://doi.org/10.1101/2020.07.30.229443

Share This Article:

Citation Tools

Small-hairpin RNAs cause target-independent microRNA dysregulation in neurons and elicit global transcriptomic changes

Rafi Kohen, Katherine T. Baldwin, Patricia M. Garay, Takao Tsukahara, Alex Chen, Corey G. Flynn, Craig Johnson, Xiao-Feng Zhao, Michael A. Sutton, Shigeki Iwase, Roman J. Giger

bioRxiv 2020.07.30.229443; doi: https://doi.org/10.1101/2020.07.30.229443

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Neuroscience

Subject Areas

All Articles

Animal Behavior and Cognition (2543)
Biochemistry (4994)
Bioengineering (3497)
Bioinformatics (15279)
Biophysics (6926)
Cancer Biology (5427)
Cell Biology (7771)
Clinical Trials (138)
Developmental Biology (4558)
Ecology (7180)
Epidemiology (2059)
Evolutionary Biology (10261)
Genetics (7532)
Genomics (9826)
Immunology (4899)
Microbiology (13304)
Molecular Biology (5165)
Neuroscience (29569)
Paleontology (203)
Pathology (842)
Pharmacology and Toxicology (1470)
Physiology (2153)
Plant Biology (4780)
Scientific Communication and Education (1015)
Synthetic Biology (1343)
Systems Biology (4022)
Zoology (771)