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Bridging the Gap: From Neuroanatomical Knowledge to Tractography of Brain Pathways

View ORCID ProfileGuillermo Gallardo, View ORCID ProfileDemian Wassermann, Alfred Anwander
doi: https://doi.org/10.1101/2020.08.01.232116
Guillermo Gallardo
1Max Planck Institute for Cognitive and Brain Sciences, Department of Neuropsychology, Leipzig, Germany
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  • For correspondence: gallardo@cbs.mpg.de
Demian Wassermann
2Parietal, Inria Saclay Île-de-France, CEA, Université Paris-Sud, 1 Rue Honoré d’Estienne d’Orves, 91120 Palaiseau, France
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Alfred Anwander
1Max Planck Institute for Cognitive and Brain Sciences, Department of Neuropsychology, Leipzig, Germany
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Abstract

Despite recent advances in tractography, the gap remains wide between the descriptions of white-matter pathways in the literature and the methods to reconstruct and study them from dMRI images. Here, we tackle this challenge by proposing a language to define white matter tracts, namely WMQLT, and a tool to automatically reconstruct pathways from their WMQLT queries. Our method is performant, flexible enough to allow defining tracts using multiple modalities, and allows to extend ROI-based reconstruction methods. Leveraging our language, we define 19 major brain tracts, alongside their subdivisions, and reconstruct them in a large population. We show that the shape of the reconstructed pathways, as well as their connectivity and lateralizations are in accordance with the current neuroanatomical literature. Finally, we showcase our technique in two scenarios: computing the functional subdivisions of a tract, and assessing the role of handedness and gender in the lateralization of language-related tracts.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 01, 2020.
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Bridging the Gap: From Neuroanatomical Knowledge to Tractography of Brain Pathways
Guillermo Gallardo, Demian Wassermann, Alfred Anwander
bioRxiv 2020.08.01.232116; doi: https://doi.org/10.1101/2020.08.01.232116
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Bridging the Gap: From Neuroanatomical Knowledge to Tractography of Brain Pathways
Guillermo Gallardo, Demian Wassermann, Alfred Anwander
bioRxiv 2020.08.01.232116; doi: https://doi.org/10.1101/2020.08.01.232116

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