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Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes
Michael J. Ormsby, Heather Hulme, Victor H. Villar, Gregory Hamm, Giovanny Rodriguez-Blanco, Ryan A. Bragg, Nicole Strittmatter, Christopher J. Schofield, Christian Delles, Ian P. Salt, Saverio Tardito, Richard Burchmore, Richard J. A. Goodwin, View ORCID ProfileDaniel M. Wall
doi: https://doi.org/10.1101/2020.08.02.232447
Michael J. Ormsby
1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow G12 8TA, United Kingdom
Heather Hulme
2Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom
Victor H. Villar
3Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom
Gregory Hamm
2Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom
Giovanny Rodriguez-Blanco
3Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom
Ryan A. Bragg
4Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom
Nicole Strittmatter
2Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom
Christopher J. Schofield
5Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom
Christian Delles
6Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
Ian P. Salt
6Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
Saverio Tardito
3Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kingdom
7Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom
Richard Burchmore
1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow G12 8TA, United Kingdom
Richard J. A. Goodwin
2Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom
1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow G12 8TA, United Kingdom
Daniel M. Wall
1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow G12 8TA, United Kingdom
Article usage
Posted August 02, 2020.
Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes
Michael J. Ormsby, Heather Hulme, Victor H. Villar, Gregory Hamm, Giovanny Rodriguez-Blanco, Ryan A. Bragg, Nicole Strittmatter, Christopher J. Schofield, Christian Delles, Ian P. Salt, Saverio Tardito, Richard Burchmore, Richard J. A. Goodwin, Daniel M. Wall
bioRxiv 2020.08.02.232447; doi: https://doi.org/10.1101/2020.08.02.232447
Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes
Michael J. Ormsby, Heather Hulme, Victor H. Villar, Gregory Hamm, Giovanny Rodriguez-Blanco, Ryan A. Bragg, Nicole Strittmatter, Christopher J. Schofield, Christian Delles, Ian P. Salt, Saverio Tardito, Richard Burchmore, Richard J. A. Goodwin, Daniel M. Wall
bioRxiv 2020.08.02.232447; doi: https://doi.org/10.1101/2020.08.02.232447
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