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Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys
View ORCID ProfileShi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Zhi-Fang Chen, Bin-Bin Nie, Xiao-Feng Ren, Jing Wu, Wen-Chao Wang, Ying-Zhou Hu, Yilin Gu, Long-Bao Lv, Yong Yin, Xin-Tian Hu, Zi-Long Qiu
doi: https://doi.org/10.1101/2020.08.03.233437
Shi-Hao Wu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, 200031, China
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
4Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Xiao Li
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, 200031, China
10Academy for Engineering & Technology, Fudan University, Shanghai, 200433, China
Dong-Dong Qin
9Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Kunming, Yunnan, 650500, China
Lin-Heng Zhang
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
5Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650204, China
Tian-Lin Cheng
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, 200031, China
Zhi-Fang Chen
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, 200031, China
Bin-Bin Nie
6Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
7School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Xiao-Feng Ren
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
5Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650204, China
Jing Wu
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Wen-Chao Wang
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Ying-Zhou Hu
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Yilin Gu
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Long-Bao Lv
4Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Yong Yin
8Department of Rehabilitation Medicine, Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650021, China
Xin-Tian Hu
2Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
3Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China
4Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China
Zi-Long Qiu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, 200031, China
3Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China
Article usage
Posted August 06, 2020.
Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys
Shi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Zhi-Fang Chen, Bin-Bin Nie, Xiao-Feng Ren, Jing Wu, Wen-Chao Wang, Ying-Zhou Hu, Yilin Gu, Long-Bao Lv, Yong Yin, Xin-Tian Hu, Zi-Long Qiu
bioRxiv 2020.08.03.233437; doi: https://doi.org/10.1101/2020.08.03.233437
Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys
Shi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Zhi-Fang Chen, Bin-Bin Nie, Xiao-Feng Ren, Jing Wu, Wen-Chao Wang, Ying-Zhou Hu, Yilin Gu, Long-Bao Lv, Yong Yin, Xin-Tian Hu, Zi-Long Qiu
bioRxiv 2020.08.03.233437; doi: https://doi.org/10.1101/2020.08.03.233437
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