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A computational model of homeostatic cerebellar compensation of ageing in vestibulo-ocular reflex adaptation

View ORCID ProfileNiceto R. Luque, View ORCID ProfileFrancisco Naveros, View ORCID ProfileEduardo Ros, View ORCID ProfileAngelo Arleo
doi: https://doi.org/10.1101/2020.08.03.233833
Niceto R. Luque
1Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France
2Department of Computer Architecture and Technology, University of Granada (CITIC), Granada, Spain
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  • For correspondence: nluque@ugr.es
Francisco Naveros
2Department of Computer Architecture and Technology, University of Granada (CITIC), Granada, Spain
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Eduardo Ros
2Department of Computer Architecture and Technology, University of Granada (CITIC), Granada, Spain
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Angelo Arleo
1Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France
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Abstract

The vestibulo-ocular reflex (VOR) stabilises vision during head motion. Age-related structural changes predict a linear VOR decay, whereas epidemiological data show a non-linear temporal profile. Here, we model cerebellar-dependent VOR adaptation to link structural and functional changes throughout ageing. We posit that three neurosynaptic factors codetermine VOR ageing patterns: electrical coupling between inferior olive neurons, intrinsic plasticity at Purkinje cell synapses, and long-term spike timing dependent plasticity at parallel fibre - Purkinje cell synapses as well as mossy fibre - medial vestibular nuclei synapses. Our cross-sectional simulations show that long-term plasticity acts as a global homeostatic mechanism mediating the non-linear temporal profile of VOR. Our results also suggest that intrinsic plasticity at Purkinje cells acts as a local homeostatic mechanism sustaining VOR at old ages. Importantly, longitudinal simulations show that residual fibres coding for the peak and trough of the VOR cycle constitute a predictive hallmark of VOR ageing trajectories.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* NL and FN share the first authorship

  • https://www.ugr.es/~nluque/restringido/CODE_Cerebellar_Ageing_Vestibulo_Ocular_Adaptation.rar

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 04, 2020.
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A computational model of homeostatic cerebellar compensation of ageing in vestibulo-ocular reflex adaptation
Niceto R. Luque, Francisco Naveros, Eduardo Ros, Angelo Arleo
bioRxiv 2020.08.03.233833; doi: https://doi.org/10.1101/2020.08.03.233833
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A computational model of homeostatic cerebellar compensation of ageing in vestibulo-ocular reflex adaptation
Niceto R. Luque, Francisco Naveros, Eduardo Ros, Angelo Arleo
bioRxiv 2020.08.03.233833; doi: https://doi.org/10.1101/2020.08.03.233833

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