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Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma

View ORCID ProfileSpyridon Megremis, Bede Constantinides, Paraskevi Xepapadaki, Claus Bachert, Susetta Neurath-Finotto, Tuomas Jartti, Marek L Kowalski, Alexandros Georgios Sotiropoulos, Avraam Tapinos, Tytti Vuorinen, Evangelos Andreakos, David Robertson, Nikolaos Papadopoulos
doi: https://doi.org/10.1101/2020.08.04.236067
Spyridon Megremis
1Division of Evolution and Genomic Science, University of Manchester, UK
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  • For correspondence: spyridon.megremis@manchester.ac.uk
Bede Constantinides
2Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, UK
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Paraskevi Xepapadaki
3Department of Allergy and Clinical Immunology, University of Athens, Greece
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Claus Bachert
4Upper Airways Research Laboratory, ENT-Department, University Hospital Ghent, Belgium
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Susetta Neurath-Finotto
5Department of Molecular Pneumonology, University of Erlangen-Nürnberg, Germany
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Tuomas Jartti
6Department of Paediatrics, University of Turku, Finland
7Department of Paediatrics, University of Oulu, Finland
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Marek L Kowalski
8Department of Immunology and Allergy, Medical University of Lodz, Poland
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Alexandros Georgios Sotiropoulos
9Department of Plant and Microbial Biology, University of Zurich, Switzerland
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Avraam Tapinos
1Division of Evolution and Genomic Science, University of Manchester, UK
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Tytti Vuorinen
10Department of Clinical Virology, Turku University Hospital, Finland
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Evangelos Andreakos
11Centre for Clinical, Experimental Surgery and Translational Research of the Biomedical Research Foundation of the Academy of Athens, Greece
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David Robertson
1Division of Evolution and Genomic Science, University of Manchester, UK
12Institute of Infection, Immunity and inflammation, University of Glasgow, UK
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Nikolaos Papadopoulos
1Division of Evolution and Genomic Science, University of Manchester, UK
3Department of Allergy and Clinical Immunology, University of Athens, Greece
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Abstract

Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 04, 2020.
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Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma
Spyridon Megremis, Bede Constantinides, Paraskevi Xepapadaki, Claus Bachert, Susetta Neurath-Finotto, Tuomas Jartti, Marek L Kowalski, Alexandros Georgios Sotiropoulos, Avraam Tapinos, Tytti Vuorinen, Evangelos Andreakos, David Robertson, Nikolaos Papadopoulos
bioRxiv 2020.08.04.236067; doi: https://doi.org/10.1101/2020.08.04.236067
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Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma
Spyridon Megremis, Bede Constantinides, Paraskevi Xepapadaki, Claus Bachert, Susetta Neurath-Finotto, Tuomas Jartti, Marek L Kowalski, Alexandros Georgios Sotiropoulos, Avraam Tapinos, Tytti Vuorinen, Evangelos Andreakos, David Robertson, Nikolaos Papadopoulos
bioRxiv 2020.08.04.236067; doi: https://doi.org/10.1101/2020.08.04.236067

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