New Results
Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes
Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, Thais Ealo, Helena G. Asenjo, Patricia Respuela, Sara Cruz-Molina, Wilfred F. J. van Ijcken, David Landeira, Álvaro Rada-Iglesias
doi: https://doi.org/10.1101/2020.08.05.237768
Tomás Pachano
1Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany
Víctor Sánchez-Gaya
2Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Albert Einstein 22, 39011 Santander, Spain
María Mariner-Faulí
2Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Albert Einstein 22, 39011 Santander, Spain
Thais Ealo
2Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Albert Einstein 22, 39011 Santander, Spain
Helena G. Asenjo
3Centre for Genomics and Oncological Research (GENYO), Avenue de la Ilustración 114, 18016 Granada, Spain.
4Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain
5Instituto de Investigación Biosanitaria ibs.GRANADA, Hospital Virgen de las Nieves, Granada, Spain
Patricia Respuela
2Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Albert Einstein 22, 39011 Santander, Spain
Sara Cruz-Molina
6Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, 48149 Muenster, Germany.
Wilfred F. J. van Ijcken
7Erasmus Medical Center, University of Rotterdam, Rotterdam, the Netherlands.
David Landeira
3Centre for Genomics and Oncological Research (GENYO), Avenue de la Ilustración 114, 18016 Granada, Spain.
4Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain
5Instituto de Investigación Biosanitaria ibs.GRANADA, Hospital Virgen de las Nieves, Granada, Spain
Álvaro Rada-Iglesias
1Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany
2Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/Universidad de Cantabria, Albert Einstein 22, 39011 Santander, Spain
8Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany
Posted August 05, 2020.
Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes
Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, Thais Ealo, Helena G. Asenjo, Patricia Respuela, Sara Cruz-Molina, Wilfred F. J. van Ijcken, David Landeira, Álvaro Rada-Iglesias
bioRxiv 2020.08.05.237768; doi: https://doi.org/10.1101/2020.08.05.237768
Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes
Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, Thais Ealo, Helena G. Asenjo, Patricia Respuela, Sara Cruz-Molina, Wilfred F. J. van Ijcken, David Landeira, Álvaro Rada-Iglesias
bioRxiv 2020.08.05.237768; doi: https://doi.org/10.1101/2020.08.05.237768
Subject Area
Subject Areas
- Biochemistry (11745)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14972)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28085)
- Molecular Biology (11592)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2885)
- Systems Biology (7340)
- Zoology (1651)