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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
Jeremy Luban, Rachel Sattler, Elke Mühlberger, Jason D. Graci, Liangxian Cao, Marla Weetall, Christopher Trotta, Joseph M. Colacino, Sina Bavari, Caterina Strambio-De-Castillia, Ellen L. Suder, Yetao Wang, Veronica Soloveva, Katherine Cintron-Lue, Nikolai A. Naryshkin, Mark Pykett, Ellen M. Welch, Kylie O’Keefe, Ronald Kong, Elizabeth Goodwin, Allan Jacobson, Slobodan Paessler, Stuart Peltz
doi: https://doi.org/10.1101/2020.08.05.238394
Jeremy Luban
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
2Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
3Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA
4Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA
Rachel Sattler
5Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA
Elke Mühlberger
4Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA
6Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
7National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA
Jason D. Graci
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Liangxian Cao
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Marla Weetall
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Christopher Trotta
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Joseph M. Colacino
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Sina Bavari
9United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
Caterina Strambio-De-Castillia
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Ellen L. Suder
6Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
7National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA
Yetao Wang
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Veronica Soloveva
9United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
Katherine Cintron-Lue
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Nikolai A. Naryshkin
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Mark Pykett
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Ellen M. Welch
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Kylie O’Keefe
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Ronald Kong
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Elizabeth Goodwin
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Allan Jacobson
10Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA
Slobodan Paessler
5Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA
Stuart Peltz
8PTC Therapeutics, Inc. South Plainfield, NJ 07080, USA
Article usage
Posted August 05, 2020.
The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
Jeremy Luban, Rachel Sattler, Elke Mühlberger, Jason D. Graci, Liangxian Cao, Marla Weetall, Christopher Trotta, Joseph M. Colacino, Sina Bavari, Caterina Strambio-De-Castillia, Ellen L. Suder, Yetao Wang, Veronica Soloveva, Katherine Cintron-Lue, Nikolai A. Naryshkin, Mark Pykett, Ellen M. Welch, Kylie O’Keefe, Ronald Kong, Elizabeth Goodwin, Allan Jacobson, Slobodan Paessler, Stuart Peltz
bioRxiv 2020.08.05.238394; doi: https://doi.org/10.1101/2020.08.05.238394
The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
Jeremy Luban, Rachel Sattler, Elke Mühlberger, Jason D. Graci, Liangxian Cao, Marla Weetall, Christopher Trotta, Joseph M. Colacino, Sina Bavari, Caterina Strambio-De-Castillia, Ellen L. Suder, Yetao Wang, Veronica Soloveva, Katherine Cintron-Lue, Nikolai A. Naryshkin, Mark Pykett, Ellen M. Welch, Kylie O’Keefe, Ronald Kong, Elizabeth Goodwin, Allan Jacobson, Slobodan Paessler, Stuart Peltz
bioRxiv 2020.08.05.238394; doi: https://doi.org/10.1101/2020.08.05.238394
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