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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

Jiuxin Qu, Zhao Cai, Yumei Liu, XiangKe Duan, Shuhong Han, Yuao Zhu, Zhaofang Jiang, Yingdan Zhang, Chao Zhuo, Yang Liu, Yingxia Liu, Lei Liu, Liang Yang
doi: https://doi.org/10.1101/2020.08.05.238998
Jiuxin Qu
1Department of Clinical Laboratory, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, 518000, Shenzhen, Guangdong, China
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Zhao Cai
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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Yumei Liu
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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XiangKe Duan
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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Shuhong Han
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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Yuao Zhu
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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Zhaofang Jiang
1Department of Clinical Laboratory, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, 518000, Shenzhen, Guangdong, China
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Yingdan Zhang
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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Chao Zhuo
3The state key laboratory of respiratory diseases, the first affiliated hospital of Guangzhou Medical University, 510120, Guangzhou, Guangdong, China
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Yang Liu
4Medical Research Center, Southern University of Science and Technology Hospital, Shenzhen, Guangdong Province, China, 518055, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China, 518055
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Yingxia Liu
1Department of Clinical Laboratory, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, 518000, Shenzhen, Guangdong, China
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Lei Liu
1Department of Clinical Laboratory, Shenzhen Third People’s Hospital, Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, 518000, Shenzhen, Guangdong, China
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  • For correspondence: Liulei3322@aliyun.com yangl@sustech.edu.cn
Liang Yang
2School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China
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  • For correspondence: Liulei3322@aliyun.com yangl@sustech.edu.cn
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Abstract

This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted August 06, 2020.
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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer
Jiuxin Qu, Zhao Cai, Yumei Liu, XiangKe Duan, Shuhong Han, Yuao Zhu, Zhaofang Jiang, Yingdan Zhang, Chao Zhuo, Yang Liu, Yingxia Liu, Lei Liu, Liang Yang
bioRxiv 2020.08.05.238998; doi: https://doi.org/10.1101/2020.08.05.238998
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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer
Jiuxin Qu, Zhao Cai, Yumei Liu, XiangKe Duan, Shuhong Han, Yuao Zhu, Zhaofang Jiang, Yingdan Zhang, Chao Zhuo, Yang Liu, Yingxia Liu, Lei Liu, Liang Yang
bioRxiv 2020.08.05.238998; doi: https://doi.org/10.1101/2020.08.05.238998

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