Prime editing primarily induces undesired outcomes in mice

Tomomi Aida; Jonathan J. Wilde; Lixin Yang; Yuanyuan Hou; Mengqi Li; Dongdong Xu; Jianbang Lin; Peimin Qi; Zhonghua Lu; Guoping Feng

doi:10.1101/2020.08.06.239723

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Prime editing primarily induces undesired outcomes in mice

Tomomi Aida, View ORCID ProfileJonathan J. Wilde, Lixin Yang, Yuanyuan Hou, Mengqi Li, Dongdong Xu, Jianbang Lin, Peimin Qi, Zhonghua Lu, Guoping Feng

doi: https://doi.org/10.1101/2020.08.06.239723

Tomomi Aida

1McGovern Institute for Brain Research, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA

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For correspondence: aidat@mit.edu wildej@mit.edu zh.lu@siat.ac.cn fengg@mit.edu

Jonathan J. Wilde

1McGovern Institute for Brain Research, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA

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ORCID record for Jonathan J. Wilde
For correspondence: aidat@mit.edu wildej@mit.edu zh.lu@siat.ac.cn fengg@mit.edu

Lixin Yang

3Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, China

4University of Chinese Academy of Sciences, Beijing, China