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An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
View ORCID ProfileMichael Schoof, View ORCID ProfileBryan Faust, View ORCID ProfileReuben A. Saunders, View ORCID ProfileSmriti Sangwan, View ORCID ProfileVeronica Rezelj, View ORCID ProfileNick Hoppe, View ORCID ProfileMorgane Boone, View ORCID ProfileChristian B. Billesbølle, View ORCID ProfileCristina Puchades, View ORCID ProfileCaleigh M. Azumaya, View ORCID ProfileHuong T. Kratochvil, View ORCID ProfileMarcell Zimanyi, View ORCID ProfileIshan Deshpande, View ORCID ProfileJiahao Liang, Sasha Dickinson, Henry C. Nguyen, Cynthia M. Chio, Gregory E. Merz, Michael C. Thompson, Devan Diwanji, Kaitlin Schaefer, View ORCID ProfileAditya A. Anand, View ORCID ProfileNiv Dobzinski, View ORCID ProfileBeth Shoshana Zha, View ORCID ProfileCamille R. Simoneau, View ORCID ProfileKristoffer Leon, View ORCID ProfileKris M. White, View ORCID ProfileUn Seng Chio, Meghna Gupta, Mingliang Jin, View ORCID ProfileFei Li, View ORCID ProfileYanxin Liu, View ORCID ProfileKaihua Zhang, View ORCID ProfileDavid Bulkley, View ORCID ProfileMing Sun, Amber M. Smith, View ORCID ProfileAlexandrea N. Rizo, View ORCID ProfileFrank Moss, View ORCID ProfileAxel F. Brilot, Sergei Pourmal, View ORCID ProfileRaphael Trenker, Thomas Pospiech, Sayan Gupta, View ORCID ProfileBenjamin Barsi-Rhyne, Vladislav Belyy, View ORCID ProfileAndrew W. Barile-Hill, View ORCID ProfileSilke Nock, View ORCID ProfileYuwei Liu, View ORCID ProfileNevan J. Krogan, View ORCID ProfileCorie Y. Ralston, View ORCID ProfileDanielle L. Swaney, View ORCID ProfileAdolfo García-Sastre, View ORCID ProfileMelanie Ott, View ORCID ProfileMarco Vignuzzi, QCRG Structural Biology Consortium, View ORCID ProfilePeter Walter, View ORCID ProfileAashish Manglik
doi: https://doi.org/10.1101/2020.08.08.238469
Michael Schoof
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Bryan Faust
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Reuben A. Saunders
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
5Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA, USA
Smriti Sangwan
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Veronica Rezelj
6Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, Cedex 15, France
Nick Hoppe
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Morgane Boone
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Christian B. Billesbølle
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Cristina Puchades
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Caleigh M. Azumaya
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Huong T. Kratochvil
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Marcell Zimanyi
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Ishan Deshpande
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Jiahao Liang
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
Sasha Dickinson
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Henry C. Nguyen
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Cynthia M. Chio
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Gregory E. Merz
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Michael C. Thompson
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Devan Diwanji
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Kaitlin Schaefer
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Aditya A. Anand
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Niv Dobzinski
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Beth Shoshana Zha
7Department of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94158, USA
Camille R. Simoneau
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
11J. David Gladstone Institutes, San Francisco, CA, USA
12Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Kristoffer Leon
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
11J. David Gladstone Institutes, San Francisco, CA, USA
12Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Kris M. White
13Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
14Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Un Seng Chio
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Meghna Gupta
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Mingliang Jin
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Fei Li
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Yanxin Liu
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Kaihua Zhang
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
David Bulkley
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Ming Sun
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Amber M. Smith
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Alexandrea N. Rizo
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Frank Moss
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Axel F. Brilot
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Sergei Pourmal
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Raphael Trenker
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Thomas Pospiech
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Sayan Gupta
9Molecular Biophysics and Integrated Bioimaging and the Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Benjamin Barsi-Rhyne
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
Vladislav Belyy
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Andrew W. Barile-Hill
8Cytiva Life Sciences, Marlborough, MA, USA
Silke Nock
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Yuwei Liu
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Nevan J. Krogan
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
5Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA, USA
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
11J. David Gladstone Institutes, San Francisco, CA, USA
Corie Y. Ralston
9Molecular Biophysics and Integrated Bioimaging and the Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Danielle L. Swaney
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
5Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA, USA
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
11J. David Gladstone Institutes, San Francisco, CA, USA
Adolfo García-Sastre
13Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
14Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
15Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
16The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Melanie Ott
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
11J. David Gladstone Institutes, San Francisco, CA, USA
12Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Marco Vignuzzi
6Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, Cedex 15, France
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
Peter Walter
1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
Aashish Manglik
3Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
4Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA, USA
10Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
17Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA, USA
Article usage
Posted August 17, 2020.
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica Rezelj, Nick Hoppe, Morgane Boone, Christian B. Billesbølle, Cristina Puchades, Caleigh M. Azumaya, Huong T. Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Sasha Dickinson, Henry C. Nguyen, Cynthia M. Chio, Gregory E. Merz, Michael C. Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A. Anand, Niv Dobzinski, Beth Shoshana Zha, Camille R. Simoneau, Kristoffer Leon, Kris M. White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M. Smith, Alexandrea N. Rizo, Frank Moss, Axel F. Brilot, Sergei Pourmal, Raphael Trenker, Thomas Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W. Barile-Hill, Silke Nock, Yuwei Liu, Nevan J. Krogan, Corie Y. Ralston, Danielle L. Swaney, Adolfo García-Sastre, Melanie Ott, Marco Vignuzzi, QCRG Structural Biology Consortium, Peter Walter, Aashish Manglik
bioRxiv 2020.08.08.238469; doi: https://doi.org/10.1101/2020.08.08.238469
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica Rezelj, Nick Hoppe, Morgane Boone, Christian B. Billesbølle, Cristina Puchades, Caleigh M. Azumaya, Huong T. Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Sasha Dickinson, Henry C. Nguyen, Cynthia M. Chio, Gregory E. Merz, Michael C. Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A. Anand, Niv Dobzinski, Beth Shoshana Zha, Camille R. Simoneau, Kristoffer Leon, Kris M. White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M. Smith, Alexandrea N. Rizo, Frank Moss, Axel F. Brilot, Sergei Pourmal, Raphael Trenker, Thomas Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W. Barile-Hill, Silke Nock, Yuwei Liu, Nevan J. Krogan, Corie Y. Ralston, Danielle L. Swaney, Adolfo García-Sastre, Melanie Ott, Marco Vignuzzi, QCRG Structural Biology Consortium, Peter Walter, Aashish Manglik
bioRxiv 2020.08.08.238469; doi: https://doi.org/10.1101/2020.08.08.238469
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