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Independent respiratory and locomotor rhythms in running mice

Coralie Hérent, Séverine Diem, View ORCID ProfileGilles Fortin, View ORCID ProfileJulien Bouvier
doi: https://doi.org/10.1101/2020.08.09.242768
Coralie Hérent
1Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay 91190, Gif-sur-Yvette, France
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Séverine Diem
1Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay 91190, Gif-sur-Yvette, France
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Gilles Fortin
2Institut de Biologie de l’École Normale Supérieure (IBENS), École Normale Supérieure, CNRS, INSERM, PSL Research University, 75005 Paris, France
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Julien Bouvier
1Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay 91190, Gif-sur-Yvette, France
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  • ORCID record for Julien Bouvier
  • For correspondence: julien.bouvier@cnrs.fr
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ABSTRACT

Examining whether and how the rhythms of limb and breathing movements interact is highly informative about the mechanistic origin of hyperpnoea to exercise. However, studies have failed to reveal regularities. In particular, whether breathing frequency is inherently proportional to limb velocity and/or imposed by a synchronization of breaths to strides is still unclear. Here, we examined the specifications of respiratory changes during running in mice, the premier model for investigating, in a standardized manner, complex integrative tasks including adaptive breathing. We show that respiratory rate increases during running to a fixed and stable value, irrespective of trotting velocities and of inclination. Yet, respiratory rate was further enhanced during gallop. We also demonstrate the absence of temporal coordination of breaths to strides at any speed, intensity or gait. Our work thus highlights a hardwired mechanism that sets respiratory frequency independently of limb movements but in relation with the engaged locomotor program.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 10, 2020.
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Independent respiratory and locomotor rhythms in running mice
Coralie Hérent, Séverine Diem, Gilles Fortin, Julien Bouvier
bioRxiv 2020.08.09.242768; doi: https://doi.org/10.1101/2020.08.09.242768
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Independent respiratory and locomotor rhythms in running mice
Coralie Hérent, Séverine Diem, Gilles Fortin, Julien Bouvier
bioRxiv 2020.08.09.242768; doi: https://doi.org/10.1101/2020.08.09.242768

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